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Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus

Ivarsson, S. A. ; Marner, B. ; Lernmark, A. LU and Nilsson, K. O. LU (1988) In Diabetes 37(3). p.347-350
Abstract

Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw314-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.

Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
in
Diabetes
volume
37
issue
3
pages
4 pages
publisher
American Diabetes Association Inc.
external identifiers
  • scopus:0023869873
  • pmid:2453387
ISSN
0012-1797
DOI
10.2337/diab.37.3.347
language
English
LU publication?
no
id
28996dbc-3ec7-475b-bc76-9708b0657538
date added to LUP
2019-09-11 10:03:41
date last changed
2020-01-13 02:21:21
@article{28996dbc-3ec7-475b-bc76-9708b0657538,
  abstract     = {<p>Neonatal insulin-dependent diabetes mellitus (IDDM) occurs rarely. A sibship of two HLA-Dw314-positive boys who developed IDDM within the 1st wk of life is described. Although the HLA-D region genotype would be consistent with IDDM associated with islet autoimmunity, islet cell antibodies were negative, but both boys exhibited the presence of a novel autoantibody that reacted specifically with a conspicuous, yet unidentified, determinant in the interstitial tissue among the acinar cells. The possible relationship between this acinar nonislet autoantibody and permanent neonatal diabetes remains to be established.</p>},
  author       = {Ivarsson, S. A. and Marner, B. and Lernmark, A. and Nilsson, K. O.},
  issn         = {0012-1797},
  language     = {eng},
  month        = {01},
  number       = {3},
  pages        = {347--350},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Nonislet pancreatic autoantibodies in sibship with permanent neonatal insulin-dependent diabetes mellitus},
  url          = {http://dx.doi.org/10.2337/diab.37.3.347},
  doi          = {10.2337/diab.37.3.347},
  volume       = {37},
  year         = {1988},
}