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Intraductal papillary neoplasms of the bile ducts : a comparative study of a rare disease in Europe and Nagoya, Japan

Lluís, Núria ; Onoe, Shunsuke ; Serradilla-Martín, Mario ; Achalandabaso, Mar ; Mizuno, Takashi ; Jehaes, François ; Dasari, Bobby V.M. ; Mambrilla-Herrero, Sara ; Sparrelid, Ernesto and Balakrishnan, Anita , et al. (2024) In HPB
Abstract

Background: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB. Methods: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan. Results: A total of 85 patients (51% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64% male; median age 71 years) from Nagoya. Patients in Europe had... (More)

Background: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB. Methods: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan. Results: A total of 85 patients (51% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64% male; median age 71 years) from Nagoya. Patients in Europe had more multiple lesions (23% vs 2%, P < .001), less invasive carcinoma (42% vs 85%, P < .001), and more intrahepatic tumors (52% vs 24%, P < .001) than in Nagoya. Patients in Europe experienced less 90-day grade >3 Clavien-Dindo complications (33% vs 68%, P < .001), but higher 90-day mortality rate (7.0% vs 0%, P = .03). R0 resections (81% vs 82%) were similar. Overall survival, excluding 90-day postoperative deaths, was similar in both regions. Discussion: Despite performing more extensive resections, the low perioperative mortality rate observed in Nagoya was probably influenced by a combination of patient-, tumor-, and surgery-related factors.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
HPB
publisher
Elsevier
external identifiers
  • pmid:38307773
  • scopus:85184079777
ISSN
1365-182X
DOI
10.1016/j.hpb.2024.01.009
language
English
LU publication?
yes
id
28ae3fcb-045f-416b-abbb-06b082b1025c
date added to LUP
2024-02-27 15:15:22
date last changed
2024-04-26 19:04:15
@article{28ae3fcb-045f-416b-abbb-06b082b1025c,
  abstract     = {{<p>Background: Intraductal papillary neoplasm of the bile ducts (IPNB) is a rare disease in Western countries. The aim of this study was to compare tumor characteristics, management strategies, and outcomes between Western and Eastern patients who underwent surgical resection for IPNB. Methods: A multi-institutional retrospective series of patients with IPNB undergoing surgery between January 2010 and December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and at Nagoya University Hospital, Japan. Results: A total of 85 patients (51% male; median age 66 years) from 28 E-AHPBA centers were compared to 91 patients (64% male; median age 71 years) from Nagoya. Patients in Europe had more multiple lesions (23% vs 2%, P &lt; .001), less invasive carcinoma (42% vs 85%, P &lt; .001), and more intrahepatic tumors (52% vs 24%, P &lt; .001) than in Nagoya. Patients in Europe experienced less 90-day grade &gt;3 Clavien-Dindo complications (33% vs 68%, P &lt; .001), but higher 90-day mortality rate (7.0% vs 0%, P = .03). R0 resections (81% vs 82%) were similar. Overall survival, excluding 90-day postoperative deaths, was similar in both regions. Discussion: Despite performing more extensive resections, the low perioperative mortality rate observed in Nagoya was probably influenced by a combination of patient-, tumor-, and surgery-related factors.</p>}},
  author       = {{Lluís, Núria and Onoe, Shunsuke and Serradilla-Martín, Mario and Achalandabaso, Mar and Mizuno, Takashi and Jehaes, François and Dasari, Bobby V.M. and Mambrilla-Herrero, Sara and Sparrelid, Ernesto and Balakrishnan, Anita and Hoogwater, Frederik J.H. and Amaral, María J. and Andersson, Bodil and Berrevoet, Frederik and Doussot, Alexandre and López-López, Víctor and Detry, Olivier and Pozo, Carlos Domingo del and Machairas, Nikolaos and Pekli, Damján and Alcázar-López, Cándido F. and Asbun, Horacio and Björnsson, Bergthor and Christophides, Thalis and Díez-Caballero, Alberto and Francart, David and Noel, Colin B. and Sousa-Silva, Donzília and Toledo-Martínez, Enrique and Tzimas, George N. and Yaqub, Sheraz and Yamaguchi, Junpei and Dokmak, Safi and Prieto-Calvo, Mikel and D'Souza, Melroy A. and Spiers, Harry V.M. and van den Heuvel, Marius C. and Charco, Ramón and Lesurtel, Mickaël and Ebata, Tomoki and Ramia, José M.}},
  issn         = {{1365-182X}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{HPB}},
  title        = {{Intraductal papillary neoplasms of the bile ducts : a comparative study of a rare disease in Europe and Nagoya, Japan}},
  url          = {{http://dx.doi.org/10.1016/j.hpb.2024.01.009}},
  doi          = {{10.1016/j.hpb.2024.01.009}},
  year         = {{2024}},
}