Psychiatric manifestations of inborn errors of metabolism : A systematic review
(2023) In Neuroscience and Biobehavioral Reviews 144.- Abstract
Inborn errors of metabolism (IEMs) are characterized by deficits in metabolic enzymes as a result of an inherited disease, leading to the accumulation or decreased excretion of proteins, carbohydrates and lipids. Although IEMs are often diagnosed during childhood, adolescent and adult onset variants may be accompanied by less somatic and more psychiatric manifestations, which often hampers recognition by psychiatrists of the distinction between a primary and secondary psychiatric disorder. To help clinicians in the diagnostic process, we aimed to provide an overview of psychiatric manifestations in IEMs. Our literature search yielded 4380 records in total, of which 88 studies were included in the qualitative synthesis. Reported... (More)
Inborn errors of metabolism (IEMs) are characterized by deficits in metabolic enzymes as a result of an inherited disease, leading to the accumulation or decreased excretion of proteins, carbohydrates and lipids. Although IEMs are often diagnosed during childhood, adolescent and adult onset variants may be accompanied by less somatic and more psychiatric manifestations, which often hampers recognition by psychiatrists of the distinction between a primary and secondary psychiatric disorder. To help clinicians in the diagnostic process, we aimed to provide an overview of psychiatric manifestations in IEMs. Our literature search yielded 4380 records in total, of which 88 studies were included in the qualitative synthesis. Reported psychiatric disorders in adolescent and adult IEMs included depression, anxiety disorder, psychosis, attention deficit hyperactivity disorder, autism spectrum disorder, bipolar disorder and obsessive-compulsive disorder as assessed by semi-structured diagnostic interviews and validated questionnaires. A diagnostic screener and multidisciplinary IEM clinics are proposed to help clinicians during the diagnostic process, to prevent diagnostic delay and to raise awareness of the psychiatric manifestations among IEMs.
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- author
- van de Burgt, Nikita ; van Doesum, Willem ; Grevink, Mirjam ; van Niele, Stephanie ; de Koning, Tom LU ; Leibold, Nicole ; Martinez-Martinez, Pilar ; van Amelsvoort, Therese and Cath, Danielle
- organization
- publishing date
- 2023-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Inborn errors of metabolism, Inherited metabolic disorders, Inherited mitochondrial disorders, Psychiatric disorders, Psychiatry
- in
- Neuroscience and Biobehavioral Reviews
- volume
- 144
- article number
- 104970
- publisher
- Elsevier
- external identifiers
-
- scopus:85142706774
- pmid:36436739
- ISSN
- 0149-7634
- DOI
- 10.1016/j.neubiorev.2022.104970
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: We would like to thank Ineke Olsman, librarian of GGZ Drenthe, for her assistance in preparing and executing the search strategy for this systematic review. Publisher Copyright: © 2022 The Authors
- id
- 28ec17cd-d4f7-487a-9b6a-2ca1ffb1327d
- date added to LUP
- 2022-12-12 08:22:47
- date last changed
- 2024-06-13 21:22:16
@article{28ec17cd-d4f7-487a-9b6a-2ca1ffb1327d,
abstract = {{<p>Inborn errors of metabolism (IEMs) are characterized by deficits in metabolic enzymes as a result of an inherited disease, leading to the accumulation or decreased excretion of proteins, carbohydrates and lipids. Although IEMs are often diagnosed during childhood, adolescent and adult onset variants may be accompanied by less somatic and more psychiatric manifestations, which often hampers recognition by psychiatrists of the distinction between a primary and secondary psychiatric disorder. To help clinicians in the diagnostic process, we aimed to provide an overview of psychiatric manifestations in IEMs. Our literature search yielded 4380 records in total, of which 88 studies were included in the qualitative synthesis. Reported psychiatric disorders in adolescent and adult IEMs included depression, anxiety disorder, psychosis, attention deficit hyperactivity disorder, autism spectrum disorder, bipolar disorder and obsessive-compulsive disorder as assessed by semi-structured diagnostic interviews and validated questionnaires. A diagnostic screener and multidisciplinary IEM clinics are proposed to help clinicians during the diagnostic process, to prevent diagnostic delay and to raise awareness of the psychiatric manifestations among IEMs.</p>}},
author = {{van de Burgt, Nikita and van Doesum, Willem and Grevink, Mirjam and van Niele, Stephanie and de Koning, Tom and Leibold, Nicole and Martinez-Martinez, Pilar and van Amelsvoort, Therese and Cath, Danielle}},
issn = {{0149-7634}},
keywords = {{Inborn errors of metabolism; Inherited metabolic disorders; Inherited mitochondrial disorders; Psychiatric disorders; Psychiatry}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Neuroscience and Biobehavioral Reviews}},
title = {{Psychiatric manifestations of inborn errors of metabolism : A systematic review}},
url = {{http://dx.doi.org/10.1016/j.neubiorev.2022.104970}},
doi = {{10.1016/j.neubiorev.2022.104970}},
volume = {{144}},
year = {{2023}},
}