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Risk of schizophrenia in relation to parental origin and genome-wide divergence

Pedersen, C. B.; Demontis, D.; Pedersen, M. S.; Agerbo, E.; Mortensen, P. B.; Borglum, A. D.; Hougaard, D. M.; Hollegaard, M. V.; Mors, O. and Cantor-Graae, Elizabeth LU (2012) In Psychological Medicine 42(7). p.1515-1521
Abstract
Background. Second-generation immigrants have an increased risk of schizophrenia, a finding that still lacks a satisfactory explanation. Various operational definitions of second-generation immigrants have been used, including foreign parental country of birth. However, with increasing global migration, it is not clear that parental country of birth necessarily is informative with regard to ethnicity. We compare two independently collected measures of parental foreign ethnicity, parental foreign country of birth versus genetic divergence, based on genome-wide genotypic data, to access which measure most efficiently captures the increased risk of schizophrenia among second-generation immigrants residing in Denmark. Method. A case-control... (More)
Background. Second-generation immigrants have an increased risk of schizophrenia, a finding that still lacks a satisfactory explanation. Various operational definitions of second-generation immigrants have been used, including foreign parental country of birth. However, with increasing global migration, it is not clear that parental country of birth necessarily is informative with regard to ethnicity. We compare two independently collected measures of parental foreign ethnicity, parental foreign country of birth versus genetic divergence, based on genome-wide genotypic data, to access which measure most efficiently captures the increased risk of schizophrenia among second-generation immigrants residing in Denmark. Method. A case-control study covering all children born in Denmark since 1981 included 892 cases of schizophrenia and 883 matched controls. Genetic divergence was assessed using principal component analyses of the genotypic data. Independently, parental foreign country of birth was assessed using information recorded prospectively in the Danish Civil Registration System. We compared incidence rate ratios of schizophrenia associated with these two independently collected measures of parental foreign ethnicity. Results. People with foreign-born parents had a significantly increased risk of schizophrenia [relative risk (RR) 1.94 (95% confidence intervals (CI) 1.41-2.65)]. Genetically divergent persons also had a significant increased risk [RR 2.43 ( 95% CI 1.55-3.82)]. Mutual adjustment of parental foreign country of birth and genetic divergence showed no difference between these measures with regard to their potential impact on the results. Conclusions. In terms of RR of schizophrenia, genetic divergence and parental foreign country of birth are interchangeable entities, and both entities have validity with regard to identifying second-generation immigrants. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Genome-wide association, immigrants, principal component, schizophrenia
in
Psychological Medicine
volume
42
issue
7
pages
1515 - 1521
publisher
Cambridge University Press
external identifiers
  • wos:000304441500016
  • scopus:84861432304
ISSN
1469-8978
DOI
10.1017/S0033291711002376
language
English
LU publication?
yes
id
81c027bd-68e4-489a-b616-c48bbbd0ea78 (old id 2906457)
date added to LUP
2012-08-01 09:46:35
date last changed
2017-01-01 03:42:29
@article{81c027bd-68e4-489a-b616-c48bbbd0ea78,
  abstract     = {Background. Second-generation immigrants have an increased risk of schizophrenia, a finding that still lacks a satisfactory explanation. Various operational definitions of second-generation immigrants have been used, including foreign parental country of birth. However, with increasing global migration, it is not clear that parental country of birth necessarily is informative with regard to ethnicity. We compare two independently collected measures of parental foreign ethnicity, parental foreign country of birth versus genetic divergence, based on genome-wide genotypic data, to access which measure most efficiently captures the increased risk of schizophrenia among second-generation immigrants residing in Denmark. Method. A case-control study covering all children born in Denmark since 1981 included 892 cases of schizophrenia and 883 matched controls. Genetic divergence was assessed using principal component analyses of the genotypic data. Independently, parental foreign country of birth was assessed using information recorded prospectively in the Danish Civil Registration System. We compared incidence rate ratios of schizophrenia associated with these two independently collected measures of parental foreign ethnicity. Results. People with foreign-born parents had a significantly increased risk of schizophrenia [relative risk (RR) 1.94 (95% confidence intervals (CI) 1.41-2.65)]. Genetically divergent persons also had a significant increased risk [RR 2.43 ( 95% CI 1.55-3.82)]. Mutual adjustment of parental foreign country of birth and genetic divergence showed no difference between these measures with regard to their potential impact on the results. Conclusions. In terms of RR of schizophrenia, genetic divergence and parental foreign country of birth are interchangeable entities, and both entities have validity with regard to identifying second-generation immigrants.},
  author       = {Pedersen, C. B. and Demontis, D. and Pedersen, M. S. and Agerbo, E. and Mortensen, P. B. and Borglum, A. D. and Hougaard, D. M. and Hollegaard, M. V. and Mors, O. and Cantor-Graae, Elizabeth},
  issn         = {1469-8978},
  keyword      = {Genome-wide association,immigrants,principal component,schizophrenia},
  language     = {eng},
  number       = {7},
  pages        = {1515--1521},
  publisher    = {Cambridge University Press},
  series       = {Psychological Medicine},
  title        = {Risk of schizophrenia in relation to parental origin and genome-wide divergence},
  url          = {http://dx.doi.org/10.1017/S0033291711002376},
  volume       = {42},
  year         = {2012},
}