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Meta-analysis identifies six new susceptibility loci for atrial fibrillation

Ellinor, Patrick T.; Lunetta, Kathryn L.; Albert, Christine M.; Glazer, Nicole L.; Ritchie, Marylyn D.; Smith, Albert V.; Arking, Dan E.; Mueller-Nurasyid, Martina; Krijthe, Bouwe P. and Lubitz, Steven A., et al. (2012) In Nature Genetics 44(6). p.88-670
Abstract
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that... (More)
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules. (Less)
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Nature Genetics
volume
44
issue
6
pages
88 - 670
publisher
Nature Publishing Group
external identifiers
  • wos:000304551100013
  • scopus:84861636519
ISSN
1546-1718
DOI
10.1038/ng.2261
language
English
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yes
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13666abe-844c-465c-877e-0c7b0f3582c4 (old id 2906770)
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2012-08-01 09:47:07
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2017-11-19 04:02:24
@article{13666abe-844c-465c-877e-0c7b0f3582c4,
  abstract     = {Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P &lt; 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.},
  author       = {Ellinor, Patrick T. and Lunetta, Kathryn L. and Albert, Christine M. and Glazer, Nicole L. and Ritchie, Marylyn D. and Smith, Albert V. and Arking, Dan E. and Mueller-Nurasyid, Martina and Krijthe, Bouwe P. and Lubitz, Steven A. and Bis, Joshua C. and Chung, Mina K. and Doerr, Marcus and Ozaki, Kouichi and Roberts, Jason D. and Smith, Gustav and Pfeufer, Arne and Sinner, Moritz F. and Lohman, Kurt and Ding, Jingzhong and Smith, Nicholas L. and Smith, Jonathan D. and Rienstra, Michiel and Rice, Kenneth M. and Van Wagoner, David R. and Magnani, Jared W. and Wakili, Reza and Clauss, Sebastian and Rotter, Jerome I. and Steinbeck, Gerhard and Launer, Lenore J. and Davies, Robert W. and Borkovich, Matthew and Harris, Tamara B. and Lin, Honghuang and Voelker, Uwe and Voelzke, Henry and Milan, David J. and Hofman, Albert and Boerwinkle, Eric and Chen, Lin Y. and Soliman, Elsayed Z. and Voight, Benjamin F. and Li, Guo and Chakravarti, Aravinda and Kubo, Michiaki and Tedrow, Usha B. and Rose, Lynda M. and Ridker, Paul M. and Conen, David and Tsunoda, Tatsuhiko and Furukawa, Tetsushi and Sotoodehnia, Nona and Xu, Siyan and Kamatani, Naoyuki and Levy, Daniel and Nakamura, Yusuke and Parvez, Babar and Mahida, Saagar and Furie, Karen L. and Rosand, Jonathan and Muhammad, Raafia and Psaty, Bruce M. and Meitinger, Thomas and Perz, Siegfried and Wichmann, H-Erich and Witteman, Jacqueline C. M. and Kao, W. H. Linda and Kathiresan, Sekar and Roden, Dan M. and Uitterlinden, Andre G. and Rivadeneira, Fernando and McKnight, Barbara and Sjögren, Marketa and Newman, Anne B. and Liu, Yongmei and Gollob, Michael H. and Melander, Olle and Tanaka, Toshihiro and Stricker, Bruno H. Ch and Felix, Stephan B. and Alonso, Alvaro and Darbar, Dawood and Barnard, John and Chasman, Daniel I. and Heckbert, Susan R. and Benjamin, Emelia J. and Gudnason, Vilmundur and Kaeaeb, Stefan},
  issn         = {1546-1718},
  language     = {eng},
  number       = {6},
  pages        = {88--670},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Meta-analysis identifies six new susceptibility loci for atrial fibrillation},
  url          = {http://dx.doi.org/10.1038/ng.2261},
  volume       = {44},
  year         = {2012},
}