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Satellite cells and myonuclei in young and elderly women and men

Kadi, F; Charifi, N; Denis, C and Lexell, Jan LU (2004) In Muscle and Nerve 29(1). p.120-127
Abstract
The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20-32 years; n = 31) and elderly (age range, 70-83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192-241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had A significantly lower (P < 0.011) number of satellite cells per muscle fiber but a significantly higher (P... (More)
The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20-32 years; n = 31) and elderly (age range, 70-83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192-241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had A significantly lower (P < 0.011) number of satellite cells per muscle fiber but a significantly higher (P < 0.004) number of myonuclei per muscle fiber. The number of satellite cells relative to the total number of nuclei [satellite cells/(myonuclei + satellite cells)] was significantly lower in the elderly than in the young women and men. These results imply that a reduction in the satellite cell population occurs as a result of increasing age in healthy men and women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sex characteristics, satellite cells, myonuclei, aging, muscle fibers
in
Muscle and Nerve
volume
29
issue
1
pages
120 - 127
publisher
John Wiley & Sons
external identifiers
  • wos:000187747100014
  • pmid:14694507
  • scopus:0347361625
ISSN
0148-639X
DOI
10.1002/mus.10510
language
English
LU publication?
yes
id
f3fefeb1-c3b7-4689-812f-fa9cf8986277 (old id 290950)
date added to LUP
2007-10-23 15:20:25
date last changed
2017-10-22 03:50:21
@article{f3fefeb1-c3b7-4689-812f-fa9cf8986277,
  abstract     = {The overall aim of this study was to assess the effects of aging on the satellite cell population. Muscle biopsies were taken from the tibialis anterior muscle of healthy, moderately active young (age range, 20-32 years; n = 31) and elderly (age range, 70-83 years; n = 27) women and men with comparable physical activity pattern. Satellite cells and myonuclei were visualized using a monoclonal antibody against neural cell adhesion molecule and counterstained with Mayer's hematoxylin. An average of 211 (range, 192-241) muscle fibers were examined for each individual. Compared with the young women and men, the elderly subjects had A significantly lower (P &lt; 0.011) number of satellite cells per muscle fiber but a significantly higher (P &lt; 0.004) number of myonuclei per muscle fiber. The number of satellite cells relative to the total number of nuclei [satellite cells/(myonuclei + satellite cells)] was significantly lower in the elderly than in the young women and men. These results imply that a reduction in the satellite cell population occurs as a result of increasing age in healthy men and women.},
  author       = {Kadi, F and Charifi, N and Denis, C and Lexell, Jan},
  issn         = {0148-639X},
  keyword      = {sex characteristics,satellite cells,myonuclei,aging,muscle fibers},
  language     = {eng},
  number       = {1},
  pages        = {120--127},
  publisher    = {John Wiley & Sons},
  series       = {Muscle and Nerve},
  title        = {Satellite cells and myonuclei in young and elderly women and men},
  url          = {http://dx.doi.org/10.1002/mus.10510},
  volume       = {29},
  year         = {2004},
}