No evidence for linkage in Swedish multiplex T1DM families to IL12B on chromosome 5q33-34
(2003) In Annals of the New York Academy of Sciences 1005. p.352-355- Abstract
- Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the 0 cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and association of IL12 to T1DM have been reported previously. We are unable to replicate this linkage on chromosome 5q33-34 in 184 Swedish families. Further, we exclude a gene with lambda(s) > 1.4 from this region. Together with previously published findings, these data make IL12 an unlikely major susceptibility gene for T1DM.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/291435
- author
- Holm, P ; Luthman, Holger LU and Kockum, I
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- transmission distortion, IL12B, type 1 diabetes mellitus (T1DM), IL12, test (TDT), linkage
- in
- Annals of the New York Academy of Sciences
- volume
- 1005
- pages
- 352 - 355
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000187496100056
- pmid:14679090
- scopus:1942506780
- ISSN
- 0077-8923
- DOI
- 10.1196/annals.1288.057
- language
- English
- LU publication?
- yes
- id
- 505b2d8f-bacf-48fe-9b48-c6db46c881fa (old id 291435)
- date added to LUP
- 2016-04-01 16:14:35
- date last changed
- 2022-01-28 18:17:43
@article{505b2d8f-bacf-48fe-9b48-c6db46c881fa, abstract = {{Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the 0 cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and association of IL12 to T1DM have been reported previously. We are unable to replicate this linkage on chromosome 5q33-34 in 184 Swedish families. Further, we exclude a gene with lambda(s) > 1.4 from this region. Together with previously published findings, these data make IL12 an unlikely major susceptibility gene for T1DM.}}, author = {{Holm, P and Luthman, Holger and Kockum, I}}, issn = {{0077-8923}}, keywords = {{transmission distortion; IL12B; type 1 diabetes mellitus (T1DM); IL12; test (TDT); linkage}}, language = {{eng}}, pages = {{352--355}}, publisher = {{Wiley-Blackwell}}, series = {{Annals of the New York Academy of Sciences}}, title = {{No evidence for linkage in Swedish multiplex T1DM families to IL12B on chromosome 5q33-34}}, url = {{http://dx.doi.org/10.1196/annals.1288.057}}, doi = {{10.1196/annals.1288.057}}, volume = {{1005}}, year = {{2003}}, }