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No evidence for linkage in Swedish multiplex T1DM families to IL12B on chromosome 5q33-34

Holm, P; Luthman, Holger LU and Kockum, I (2003) In Annals of the New York Academy of Sciences 1005. p.352-355
Abstract
Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the 0 cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and association of IL12 to T1DM have been reported previously. We are unable to replicate this linkage on chromosome 5q33-34 in 184 Swedish families. Further, we exclude a gene with lambda(s) > 1.4 from this region. Together with previously published findings, these data make IL12 an unlikely major susceptibility gene for T1DM.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transmission distortion, IL12B, type 1 diabetes mellitus (T1DM), IL12, test (TDT), linkage
in
Annals of the New York Academy of Sciences
volume
1005
pages
352 - 355
publisher
New York Academy of Sciences
external identifiers
  • wos:000187496100056
  • pmid:14679090
  • scopus:1942506780
ISSN
0077-8923
DOI
10.1196/annals.1288.057
language
English
LU publication?
yes
id
505b2d8f-bacf-48fe-9b48-c6db46c881fa (old id 291435)
date added to LUP
2007-09-13 10:49:47
date last changed
2018-10-04 13:36:33
@article{505b2d8f-bacf-48fe-9b48-c6db46c881fa,
  abstract     = {Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the 0 cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and association of IL12 to T1DM have been reported previously. We are unable to replicate this linkage on chromosome 5q33-34 in 184 Swedish families. Further, we exclude a gene with lambda(s) > 1.4 from this region. Together with previously published findings, these data make IL12 an unlikely major susceptibility gene for T1DM.},
  author       = {Holm, P and Luthman, Holger and Kockum, I},
  issn         = {0077-8923},
  keyword      = {transmission distortion,IL12B,type 1 diabetes mellitus (T1DM),IL12,test (TDT),linkage},
  language     = {eng},
  pages        = {352--355},
  publisher    = {New York Academy of Sciences},
  series       = {Annals of the New York Academy of Sciences},
  title        = {No evidence for linkage in Swedish multiplex T1DM families to IL12B on chromosome 5q33-34},
  url          = {http://dx.doi.org/10.1196/annals.1288.057},
  volume       = {1005},
  year         = {2003},
}