Networks of inflammation, depression, and cognition in aging males and females
(2022) In Aging clinical and experimental research- Abstract
- Background
Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.
Aims
To explore the interactive network of inflammation, depression and cognition by sex in older people.
Methods
We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70–90 years), non-demented, community-dwelling sample from the longitudinal Sydney... (More) - Background
Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.
Aims
To explore the interactive network of inflammation, depression and cognition by sex in older people.
Methods
We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70–90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up.
Results
The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers.
Conclusions
These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/291833fa-ee2a-441b-9489-b633306a63c7
- author
- Chalmers, Rebecca ; Cervin, Matti LU ; Choo, Carol ; Baune, Bernhard ; Trollor, Julian ; Numbers, Katya ; Sachdev, Perminder ; Brodaty, Henry ; Kochan, Nicole and Medvedev, Oleg
- organization
- publishing date
- 2022-07-27
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Aging clinical and experimental research
- publisher
- Kurtis
- external identifiers
-
- scopus:85135469073
- pmid:35895279
- ISSN
- 1720-8319
- DOI
- 10.1007/s40520-022-02198-6
- language
- English
- LU publication?
- yes
- id
- 291833fa-ee2a-441b-9489-b633306a63c7
- alternative location
- https://link.springer.com/article/10.1007/s40520-022-02198-6
- date added to LUP
- 2022-07-31 11:36:31
- date last changed
- 2022-10-12 03:00:02
@article{291833fa-ee2a-441b-9489-b633306a63c7,
abstract = {{Background<br/>Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.<br/><br/>Aims<br/>To explore the interactive network of inflammation, depression and cognition by sex in older people.<br/><br/>Methods<br/>We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70–90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up.<br/><br/>Results<br/>The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers.<br/><br/>Conclusions<br/>These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging.}},
author = {{Chalmers, Rebecca and Cervin, Matti and Choo, Carol and Baune, Bernhard and Trollor, Julian and Numbers, Katya and Sachdev, Perminder and Brodaty, Henry and Kochan, Nicole and Medvedev, Oleg}},
issn = {{1720-8319}},
language = {{eng}},
month = {{07}},
publisher = {{Kurtis}},
series = {{Aging clinical and experimental research}},
title = {{Networks of inflammation, depression, and cognition in aging males and females}},
url = {{http://dx.doi.org/10.1007/s40520-022-02198-6}},
doi = {{10.1007/s40520-022-02198-6}},
year = {{2022}},
}