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N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: A randomized controlled trial

Ahola, T; Lapatto, R; Raivio, KO; Selander, Bo LU ; Stigson, L; Jonsson, B; Jonsbo, F; Esberg, G; Stovring, S and Kjartansson, S, et al. (2003) In Journal of Pediatrics 143(6). p.713-719
Abstract
Objective To evaluate whether N-acetyleysteine (NAC) infusion during the first week of life reduces the risk of death or bronchopulmonary dysplasia (BPD in infants with extremely low birth weight. Study design In a Nordic multicenter, double-blind trial, infants (n = 391) weighing 500 to 999 g and on ventilator or nasal continuous positive airway pressure were randomized before the age of 36 hours to receive NAC 16 to 32 mg/kg/d (n = 194) or placebo (n = 197) intravenously for 6 days. Primary end points were death or BPD, defined as supplementary oxygen requirement at 36 weeks' gestational age. Results There was no difference in the combined incidence of the primary end points death or BPD, 51% vs. 49%, between the NAC group and control... (More)
Objective To evaluate whether N-acetyleysteine (NAC) infusion during the first week of life reduces the risk of death or bronchopulmonary dysplasia (BPD in infants with extremely low birth weight. Study design In a Nordic multicenter, double-blind trial, infants (n = 391) weighing 500 to 999 g and on ventilator or nasal continuous positive airway pressure were randomized before the age of 36 hours to receive NAC 16 to 32 mg/kg/d (n = 194) or placebo (n = 197) intravenously for 6 days. Primary end points were death or BPD, defined as supplementary oxygen requirement at 36 weeks' gestational age. Results There was no difference in the combined incidence of the primary end points death or BPD, 51% vs. 49%, between the NAC group and control group. Also similar was the incidence of BPD in survivors at 36 weeks' gestational age, 40% vs. 40%, and the mean oxygen requirement at the age of 28 days, 31.2% vs. 30.7%, respectively. The severity of BPD was similar in both groups. Conclusions A 6-day course of intravenous N-acetylcysteine at the dosage used does not prevent BPD or death in infants with extremely low birth weight. (Less)
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Contribution to journal
publication status
published
subject
in
Journal of Pediatrics
volume
143
issue
6
pages
713 - 719
publisher
Academic Press
external identifiers
  • pmid:14657813
  • wos:000187212400008
  • scopus:0345257154
ISSN
1097-6833
DOI
10.1067/S0022-3476(03)00419-0
language
English
LU publication?
yes
id
51152983-85ed-473f-af55-86fe06bc49ee (old id 292360)
date added to LUP
2007-08-22 07:57:33
date last changed
2017-09-10 03:32:33
@article{51152983-85ed-473f-af55-86fe06bc49ee,
  abstract     = {Objective To evaluate whether N-acetyleysteine (NAC) infusion during the first week of life reduces the risk of death or bronchopulmonary dysplasia (BPD in infants with extremely low birth weight. Study design In a Nordic multicenter, double-blind trial, infants (n = 391) weighing 500 to 999 g and on ventilator or nasal continuous positive airway pressure were randomized before the age of 36 hours to receive NAC 16 to 32 mg/kg/d (n = 194) or placebo (n = 197) intravenously for 6 days. Primary end points were death or BPD, defined as supplementary oxygen requirement at 36 weeks' gestational age. Results There was no difference in the combined incidence of the primary end points death or BPD, 51% vs. 49%, between the NAC group and control group. Also similar was the incidence of BPD in survivors at 36 weeks' gestational age, 40% vs. 40%, and the mean oxygen requirement at the age of 28 days, 31.2% vs. 30.7%, respectively. The severity of BPD was similar in both groups. Conclusions A 6-day course of intravenous N-acetylcysteine at the dosage used does not prevent BPD or death in infants with extremely low birth weight.},
  author       = {Ahola, T and Lapatto, R and Raivio, KO and Selander, Bo and Stigson, L and Jonsson, B and Jonsbo, F and Esberg, G and Stovring, S and Kjartansson, S and Stiris, T and Lossius, K and Virkola, K and Fellman, V},
  issn         = {1097-6833},
  language     = {eng},
  number       = {6},
  pages        = {713--719},
  publisher    = {Academic Press},
  series       = {Journal of Pediatrics},
  title        = {N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants: A randomized controlled trial},
  url          = {http://dx.doi.org/10.1067/S0022-3476(03)00419-0},
  volume       = {143},
  year         = {2003},
}