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Global dispersion of right atrial repolarization in healthy pigs and patients

Hertervig, Eva LU ; Li, Z; Kongstad Rasmussen, Ole LU ; Holm, M; Olsson, Bertil LU and Yuan, Shiwen LU (2003) In Scandinavian Cardiovascular Journal1997-01-01+01:00 37(6). p.329-333
Abstract
Objective - To investigate the feasibility of monophasic action potential ( MAP) mapping using an electro-anatomical mapping system ( CARTO) in obtaining information on global dispersion of atrial repolarization and to evaluate the role of dispersion of repolarization in the genesis of paroxysmal atrial fibrillation ( PAF). Methods and results - Right atrial MAPs were recorded from 53 +/- 18 sites in 10 healthy pigs and 33 +/- 21 sites in 6 patients with and 4 patients without history of PAF. In pigs, the global dispersions of activation time ( AT), MAP duration and end of repolarization time ( EOR), 70 +/- 8, 95 +/- 18 and 121 +/- 28 ms, respectively, were significantly greater than those among 10, 20 and 30 sites. In patients with PAF,... (More)
Objective - To investigate the feasibility of monophasic action potential ( MAP) mapping using an electro-anatomical mapping system ( CARTO) in obtaining information on global dispersion of atrial repolarization and to evaluate the role of dispersion of repolarization in the genesis of paroxysmal atrial fibrillation ( PAF). Methods and results - Right atrial MAPs were recorded from 53 +/- 18 sites in 10 healthy pigs and 33 +/- 21 sites in 6 patients with and 4 patients without history of PAF. In pigs, the global dispersions of activation time ( AT), MAP duration and end of repolarization time ( EOR), 70 +/- 8, 95 +/- 18 and 121 +/- 28 ms, respectively, were significantly greater than those among 10, 20 and 30 sites. In patients with PAF, the global dispersions of MAP duration and EOR ( 128 +/- 10 and 149 +/- 31 ms) were significantly greater than those in patients without PAF ( 84 +/- 10 and 91 +/- 17 ms). Conclusion - MAP mapping using the CARTO system was feasible in experimental and clinical settings in obtaining information on global dispersion of atrial repolarization. The number of recording sites could significantly affect repolarization parameters. The dispersions of atrial repolarization were significantly greater in patients with PAF than those without, suggesting the involvement of an increased dispersion of repolarization in the genesis of PAF. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
action potential, monophasic, electroanatomical mapping, atrial fibrillation, dispersion, repolarization
in
Scandinavian Cardiovascular Journal1997-01-01+01:00
volume
37
issue
6
pages
329 - 333
publisher
Taylor & Francis
external identifiers
  • wos:000187186600005
  • pmid:14668182
  • scopus:0742272144
ISSN
1651-2006
DOI
10.1080/14017430310016207
language
English
LU publication?
yes
id
bb62cfd5-c6f6-43ff-aa5f-e93ec5e8422a (old id 292541)
date added to LUP
2007-09-13 08:30:55
date last changed
2018-01-07 08:43:27
@article{bb62cfd5-c6f6-43ff-aa5f-e93ec5e8422a,
  abstract     = {Objective - To investigate the feasibility of monophasic action potential ( MAP) mapping using an electro-anatomical mapping system ( CARTO) in obtaining information on global dispersion of atrial repolarization and to evaluate the role of dispersion of repolarization in the genesis of paroxysmal atrial fibrillation ( PAF). Methods and results - Right atrial MAPs were recorded from 53 +/- 18 sites in 10 healthy pigs and 33 +/- 21 sites in 6 patients with and 4 patients without history of PAF. In pigs, the global dispersions of activation time ( AT), MAP duration and end of repolarization time ( EOR), 70 +/- 8, 95 +/- 18 and 121 +/- 28 ms, respectively, were significantly greater than those among 10, 20 and 30 sites. In patients with PAF, the global dispersions of MAP duration and EOR ( 128 +/- 10 and 149 +/- 31 ms) were significantly greater than those in patients without PAF ( 84 +/- 10 and 91 +/- 17 ms). Conclusion - MAP mapping using the CARTO system was feasible in experimental and clinical settings in obtaining information on global dispersion of atrial repolarization. The number of recording sites could significantly affect repolarization parameters. The dispersions of atrial repolarization were significantly greater in patients with PAF than those without, suggesting the involvement of an increased dispersion of repolarization in the genesis of PAF.},
  author       = {Hertervig, Eva and Li, Z and Kongstad Rasmussen, Ole and Holm, M and Olsson, Bertil and Yuan, Shiwen},
  issn         = {1651-2006},
  keyword      = {action potential,monophasic,electroanatomical mapping,atrial fibrillation,dispersion,repolarization},
  language     = {eng},
  number       = {6},
  pages        = {329--333},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal1997-01-01+01:00},
  title        = {Global dispersion of right atrial repolarization in healthy pigs and patients},
  url          = {http://dx.doi.org/10.1080/14017430310016207},
  volume       = {37},
  year         = {2003},
}