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The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease : Perspectives from the Research Roundtable

Knopman, David S. ; Haeberlein, Samantha Budd ; Carrillo, Maria C. ; Hendrix, James A. ; Kerchner, Geoff ; Margolin, Richard ; Maruff, Paul ; Miller, David S. ; Tong, Gary and Tome, Maria B. , et al. (2018) In Alzheimer's and Dementia 14(4). p.563-575
Abstract

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Amyloid, Biomarkers, Clinical trials, Neurodegeneration, Tau
in
Alzheimer's and Dementia
volume
14
issue
4
pages
13 pages
publisher
Wiley
external identifiers
  • scopus:85044929982
  • pmid:29653607
ISSN
1552-5260
DOI
10.1016/j.jalz.2018.03.002
language
English
LU publication?
yes
id
2929e9a8-c003-4f92-860b-f362f6777667
date added to LUP
2018-04-19 15:55:29
date last changed
2024-06-10 11:27:06
@article{2929e9a8-c003-4f92-860b-f362f6777667,
  abstract     = {{<p>The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the “A, T, N System” (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.</p>}},
  author       = {{Knopman, David S. and Haeberlein, Samantha Budd and Carrillo, Maria C. and Hendrix, James A. and Kerchner, Geoff and Margolin, Richard and Maruff, Paul and Miller, David S. and Tong, Gary and Tome, Maria B. and Murray, Melissa E. and Nelson, Peter T. and Sano, Mary and Mattsson, Niklas and Sultzer, David L. and Montine, Thomas J. and Jack, Clifford R. and Kolb, Hartmuth and Petersen, Ronald C. and Vemuri, Prashanthi and Canniere, Megan Zoschg and Schneider, Julie A. and Resnick, Susan M. and Romano, Gary and van Harten, Argonde Corien and Wolk, David A. and Bain, Lisa J. and Siemers, Eric}},
  issn         = {{1552-5260}},
  keywords     = {{Alzheimer's disease; Amyloid; Biomarkers; Clinical trials; Neurodegeneration; Tau}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{563--575}},
  publisher    = {{Wiley}},
  series       = {{Alzheimer's and Dementia}},
  title        = {{The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease : Perspectives from the Research Roundtable}},
  url          = {{http://dx.doi.org/10.1016/j.jalz.2018.03.002}},
  doi          = {{10.1016/j.jalz.2018.03.002}},
  volume       = {{14}},
  year         = {{2018}},
}