The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis.
(2012) In Journal of Internal Medicine 272(2). p.170-176- Abstract
- Objectives: The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS(2) and CHA(2) DS(2) -VASc. Bleeding risk was assessed using the HAS-BLED score. Design: The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment. All patients with the diagnosis AF in the catchment area are registered in AURICULA. Results: Of the 65,532 inhabitants in the catchment area, 1616 were... (More)
- Objectives: The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS(2) and CHA(2) DS(2) -VASc. Bleeding risk was assessed using the HAS-BLED score. Design: The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment. All patients with the diagnosis AF in the catchment area are registered in AURICULA. Results: Of the 65,532 inhabitants in the catchment area, 1616 were diagnosed with AF (1200 cases were characterized as chronic AF). Thus, the overall prevalence of AF was 2.5%. The prevalence increased with age from 6.3% in patients over 55 years of age to 13.8% in those over 80 years. The prevalence was higher in men than in women in all age groups. Overall, 56.3% and 85.1% of the population were at high risk of stroke (≥2 points) according to CHADS(2) and CHA(2) DS(2) -VASc, respectively. In addition, 26.9% had an increased bleeding risk according to HAS-BLED. Conclusion: Within this large Caucasian population, we identified the highest community-based prevalence of AF to date. The prevalence was strongly associated with increasing age and male gender. Using CHA(2) DS(2) -VASc instead of CHADS(2) widened the indication for OAC prophylactic therapy of AF in this population. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2336315
- author
- Andersson, Per ; Löndahl, Magnus LU ; Abdon, Nils-Johan and Terent, Andreas
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Internal Medicine
- volume
- 272
- issue
- 2
- pages
- 170 - 176
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000306895300009
- pmid:22250988
- scopus:84864307121
- pmid:22250988
- ISSN
- 1365-2796
- DOI
- 10.1111/j.1365-2796.2012.02519.x
- language
- English
- LU publication?
- yes
- id
- 29345151-7732-4adf-ada2-6e54db1de008 (old id 2336315)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22250988?dopt=Abstract
- date added to LUP
- 2016-04-04 09:34:00
- date last changed
- 2024-01-12 15:19:50
@article{29345151-7732-4adf-ada2-6e54db1de008,
abstract = {{Objectives: The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS(2) and CHA(2) DS(2) -VASc. Bleeding risk was assessed using the HAS-BLED score. Design: The study population was recruited from AURICULA, a Swedish national quality register for patients receiving anticoagulation treatment. All patients with the diagnosis AF in the catchment area are registered in AURICULA. Results: Of the 65,532 inhabitants in the catchment area, 1616 were diagnosed with AF (1200 cases were characterized as chronic AF). Thus, the overall prevalence of AF was 2.5%. The prevalence increased with age from 6.3% in patients over 55 years of age to 13.8% in those over 80 years. The prevalence was higher in men than in women in all age groups. Overall, 56.3% and 85.1% of the population were at high risk of stroke (≥2 points) according to CHADS(2) and CHA(2) DS(2) -VASc, respectively. In addition, 26.9% had an increased bleeding risk according to HAS-BLED. Conclusion: Within this large Caucasian population, we identified the highest community-based prevalence of AF to date. The prevalence was strongly associated with increasing age and male gender. Using CHA(2) DS(2) -VASc instead of CHADS(2) widened the indication for OAC prophylactic therapy of AF in this population.}},
author = {{Andersson, Per and Löndahl, Magnus and Abdon, Nils-Johan and Terent, Andreas}},
issn = {{1365-2796}},
language = {{eng}},
number = {{2}},
pages = {{170--176}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Internal Medicine}},
title = {{The prevalence of atrial fibrillation in a geographically well-defined population in Northern Sweden: implications for anticoagulation prophylaxis.}},
url = {{http://dx.doi.org/10.1111/j.1365-2796.2012.02519.x}},
doi = {{10.1111/j.1365-2796.2012.02519.x}},
volume = {{272}},
year = {{2012}},
}