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Autism and auditory brain stem responses

Rosenhall, U; Nordin, Viviann LU ; Brantberg, K and Gillberg, C (2003) In Ear and Hearing 24(3). p.206-214
Abstract
Objective: To study a controversy that has been discussed for more than two decades: whether or not children with autism have abnormalities affecting the cochlear nerve or the auditory pathway in the brain stem and, if so, to describe these abnormalities. Design: A group of 153 children and adolescents with autistic disorder were included in an investigation of auditory brain stem responses (ABR). Two thirds of this group, 101 individuals (75 boys, 26 girls), had normal hearing and they were selected for an in-depth ABR study. The results from the study group were compared with those of an age-matched comparison group. Results: The III-V interpeak latency (IPL) was significantly prolonged in both boys and girls with autism, compared with... (More)
Objective: To study a controversy that has been discussed for more than two decades: whether or not children with autism have abnormalities affecting the cochlear nerve or the auditory pathway in the brain stem and, if so, to describe these abnormalities. Design: A group of 153 children and adolescents with autistic disorder were included in an investigation of auditory brain stem responses (ABR). Two thirds of this group, 101 individuals (75 boys, 26 girls), had normal hearing and they were selected for an in-depth ABR study. The results from the study group were compared with those of an age-matched comparison group. Results: The III-V interpeak latency (IPL) was significantly prolonged in both boys and girls with autism, compared with the controls. The latencies of ABR waves I and V were also significantly lengthened in the study groups. The individual test results showed that more than half of this normal-hearing autistic disorder group (58%) had abnormalities of one or more of eight ABR parameters studied. The most common abnormalities were prolongation of wave V (38%), and of I-V IPL (28%). A lengthening of the IN IPL was also recorded in 27% of 49 children who were difficult to test or who had hearing loss. Abnormal left-right differences of ABR latencies were found in 18% of autism cases with normal hearing. Conclusions: Possible causes of the reported ABR abnormalities, observed here as well as in other studies, are discussed. Brain stem lesion, occult cochlear dysfunction, and involvement of the cochlear efferent system are probable factors that can explain the ABR findings. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Ear and Hearing
volume
24
issue
3
pages
206 - 214
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:12799542
  • wos:000186787000004
  • scopus:0038809128
ISSN
1538-4667
DOI
language
English
LU publication?
yes
id
71332c7d-f3ca-4f0c-a74e-5df327e5f686 (old id 294642)
date added to LUP
2007-09-20 18:44:20
date last changed
2018-05-29 11:30:45
@article{71332c7d-f3ca-4f0c-a74e-5df327e5f686,
  abstract     = {Objective: To study a controversy that has been discussed for more than two decades: whether or not children with autism have abnormalities affecting the cochlear nerve or the auditory pathway in the brain stem and, if so, to describe these abnormalities. Design: A group of 153 children and adolescents with autistic disorder were included in an investigation of auditory brain stem responses (ABR). Two thirds of this group, 101 individuals (75 boys, 26 girls), had normal hearing and they were selected for an in-depth ABR study. The results from the study group were compared with those of an age-matched comparison group. Results: The III-V interpeak latency (IPL) was significantly prolonged in both boys and girls with autism, compared with the controls. The latencies of ABR waves I and V were also significantly lengthened in the study groups. The individual test results showed that more than half of this normal-hearing autistic disorder group (58%) had abnormalities of one or more of eight ABR parameters studied. The most common abnormalities were prolongation of wave V (38%), and of I-V IPL (28%). A lengthening of the IN IPL was also recorded in 27% of 49 children who were difficult to test or who had hearing loss. Abnormal left-right differences of ABR latencies were found in 18% of autism cases with normal hearing. Conclusions: Possible causes of the reported ABR abnormalities, observed here as well as in other studies, are discussed. Brain stem lesion, occult cochlear dysfunction, and involvement of the cochlear efferent system are probable factors that can explain the ABR findings.},
  author       = {Rosenhall, U and Nordin, Viviann and Brantberg, K and Gillberg, C},
  issn         = {1538-4667},
  language     = {eng},
  number       = {3},
  pages        = {206--214},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Ear and Hearing},
  title        = {Autism and auditory brain stem responses},
  url          = {http://dx.doi.org/},
  volume       = {24},
  year         = {2003},
}