Advanced

Biochemical serum markers for brain damage: A short review with emphasis on clinical utility in mild head injury

Ingebrigtsen, T and Romner, Bertil LU (2003) In Restorative Neurology and Neuroscience 21(3-4). p.171-176
Abstract
Purpose. To provide an overview of clinical research on the use of biochemical serum markers for traumatic brain injury (TRI) in the evaluation of patients with mild head injuries (MHI). Methods. The MEDLINE database was searched for publications on biochemical serum markers of TBI until August 2002. Clinical studies addressing their use in MHI were reviewed. Results. Desirable characteristics for biochemical serum markers of TBI were identified. Creatine kinase isoenzyme 1313 (CK-BB), neuron specific enolase (NSE) and S-100B protein have been most extensively studied. The sensitivity and specificity of CK-BB is inadequate for use as an indicator of traumatic brain injury. Serum levels of NSE do not correspond to the amount of TBI,... (More)
Purpose. To provide an overview of clinical research on the use of biochemical serum markers for traumatic brain injury (TRI) in the evaluation of patients with mild head injuries (MHI). Methods. The MEDLINE database was searched for publications on biochemical serum markers of TBI until August 2002. Clinical studies addressing their use in MHI were reviewed. Results. Desirable characteristics for biochemical serum markers of TBI were identified. Creatine kinase isoenzyme 1313 (CK-BB), neuron specific enolase (NSE) and S-100B protein have been most extensively studied. The sensitivity and specificity of CK-BB is inadequate for use as an indicator of traumatic brain injury. Serum levels of NSE do not correspond to the amount of TBI, probably because of its long (20 h) half-life. S-100B serum levels are correlated to both clinical measures of injury severity, neuroradiological findings and outcomes in several studies from different authors. Conclusion. Currently, S-100B protein is the most promising marker for evaluation of TBI in patients with MHI. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
S-100B protein, enolase, neuron specific, creatine kinase, head injury, biochemical markers, glial fibrillary acidic protein
in
Restorative Neurology and Neuroscience
volume
21
issue
3-4
pages
171 - 176
publisher
IOS Press
external identifiers
  • pmid:14530579
  • wos:000186690900009
  • scopus:0142195713
ISSN
1878-3627
language
English
LU publication?
yes
id
96fcbd63-4462-4a73-9920-a30e016fbeec (old id 294783)
alternative location
http://iospress.metapress.com/link.asp?id=9rd1ar6wkvvngagf
date added to LUP
2007-09-13 12:30:27
date last changed
2018-02-18 04:23:32
@article{96fcbd63-4462-4a73-9920-a30e016fbeec,
  abstract     = {Purpose. To provide an overview of clinical research on the use of biochemical serum markers for traumatic brain injury (TRI) in the evaluation of patients with mild head injuries (MHI). Methods. The MEDLINE database was searched for publications on biochemical serum markers of TBI until August 2002. Clinical studies addressing their use in MHI were reviewed. Results. Desirable characteristics for biochemical serum markers of TBI were identified. Creatine kinase isoenzyme 1313 (CK-BB), neuron specific enolase (NSE) and S-100B protein have been most extensively studied. The sensitivity and specificity of CK-BB is inadequate for use as an indicator of traumatic brain injury. Serum levels of NSE do not correspond to the amount of TBI, probably because of its long (20 h) half-life. S-100B serum levels are correlated to both clinical measures of injury severity, neuroradiological findings and outcomes in several studies from different authors. Conclusion. Currently, S-100B protein is the most promising marker for evaluation of TBI in patients with MHI.},
  author       = {Ingebrigtsen, T and Romner, Bertil},
  issn         = {1878-3627},
  keyword      = {S-100B protein,enolase,neuron specific,creatine kinase,head injury,biochemical markers,glial fibrillary acidic protein},
  language     = {eng},
  number       = {3-4},
  pages        = {171--176},
  publisher    = {IOS Press},
  series       = {Restorative Neurology and Neuroscience},
  title        = {Biochemical serum markers for brain damage: A short review with emphasis on clinical utility in mild head injury},
  volume       = {21},
  year         = {2003},
}