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Tlx controls proliferation and patterning of lateral telencephalic progenitor domains

Stenman, Jan LU ; Wang, B and Campbell, Kenneth LU (2003) In Journal of Neuroscience 23(33). p.10568-10576
Abstract
We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial region, i.e., the ventral pallium. We also observed a disproportionate reduction in the size of the Tlx mutant lateral ganglionic eminence (LGE) from embryonic day 14.5 onward. Here we show that this reduction is caused, at least in large part, by a proliferation defect. Interestingly, in Tlx mutants, the LGE derivatives are differentially affected. Although the development of the Tlx mutant striatum is compromised, an apparently normal number of olfactory bulb interneurons are... (More)
We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial region, i.e., the ventral pallium. We also observed a disproportionate reduction in the size of the Tlx mutant lateral ganglionic eminence (LGE) from embryonic day 14.5 onward. Here we show that this reduction is caused, at least in large part, by a proliferation defect. Interestingly, in Tlx mutants, the LGE derivatives are differentially affected. Although the development of the Tlx mutant striatum is compromised, an apparently normal number of olfactory bulb interneurons are observed. Consistent with this observation, we found that Tlx is required for the normal establishment of the ventral LGE that gives rise to striatal projection neurons. This domain is reduced by the dorsal and ventral expansion of molecular markers normally confined to progenitor domains flanking the ventral LGE. Finally, we investigated possible genetic interactions between Gsh2 and Tlx in lateral telencephalic development. Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SFRP2, Dbx1, dorsal LGE, ventral LGE, pallium, ventral, tailless, subpallium, striatum, NR2E1, GSH2, Neurogenin2, ISL1, Er81, NKX6.2
in
Journal of Neuroscience
volume
23
issue
33
pages
10568 - 10576
publisher
Society for Neuroscience
external identifiers
  • wos:000186680700012
  • scopus:0345305682
ISSN
1529-2401
language
English
LU publication?
yes
id
7032534d-fb2b-4f2c-a65e-37201ca882e7 (old id 294948)
alternative location
http://www.jneurosci.org/cgi/content/abstract/23/33/10568
date added to LUP
2007-09-22 12:41:31
date last changed
2018-10-03 11:19:30
@article{7032534d-fb2b-4f2c-a65e-37201ca882e7,
  abstract     = {We showed previously that the orphan nuclear receptor Tlx is required for the correct establishment of the pallio-subpallial boundary. Loss of Tlx results in a dorsal expansion of ventral markers (e.g., the homeodomain protein GSH2) into the ventralmost pallial region, i.e., the ventral pallium. We also observed a disproportionate reduction in the size of the Tlx mutant lateral ganglionic eminence (LGE) from embryonic day 14.5 onward. Here we show that this reduction is caused, at least in large part, by a proliferation defect. Interestingly, in Tlx mutants, the LGE derivatives are differentially affected. Although the development of the Tlx mutant striatum is compromised, an apparently normal number of olfactory bulb interneurons are observed. Consistent with this observation, we found that Tlx is required for the normal establishment of the ventral LGE that gives rise to striatal projection neurons. This domain is reduced by the dorsal and ventral expansion of molecular markers normally confined to progenitor domains flanking the ventral LGE. Finally, we investigated possible genetic interactions between Gsh2 and Tlx in lateral telencephalic development. Our results show that, although Gsh2 and Tlx have additive effects on striatal development, they differentially regulate the establishment of ventral pallial identity.},
  author       = {Stenman, Jan and Wang, B and Campbell, Kenneth},
  issn         = {1529-2401},
  keyword      = {SFRP2,Dbx1,dorsal LGE,ventral LGE,pallium,ventral,tailless,subpallium,striatum,NR2E1,GSH2,Neurogenin2,ISL1,Er81,NKX6.2},
  language     = {eng},
  number       = {33},
  pages        = {10568--10576},
  publisher    = {Society for Neuroscience},
  series       = {Journal of Neuroscience},
  title        = {Tlx controls proliferation and patterning of lateral telencephalic progenitor domains},
  volume       = {23},
  year         = {2003},
}