Advanced

Circulating oxidized low-density lipoprotein is increased in hypertension

Frostegard, J; Wu, RH; Lemne, C; Thulin, Thomas LU ; Witztum, JL and De Faire, U (2003) In Clinical Science 105(5). p.615-620
Abstract
Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from I I I men with established hypertension (diastolic pressure > 95 mmHg) from the Swedish component of an ongoing hypertension study (European Lacidipine study on Atherosclerosis, ELSA) and from 75 normotensive control men, who were from a Swedish population-screening programme (diastolic pressure < 80 mmHg). The presence of carotid atherosclerosis and the intima-media thicknesses were determined by ultrasonography. A monoclonal antibody to OxLDL,... (More)
Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from I I I men with established hypertension (diastolic pressure > 95 mmHg) from the Swedish component of an ongoing hypertension study (European Lacidipine study on Atherosclerosis, ELSA) and from 75 normotensive control men, who were from a Swedish population-screening programme (diastolic pressure < 80 mmHg). The presence of carotid atherosclerosis and the intima-media thicknesses were determined by ultrasonography. A monoclonal antibody to OxLDL, EO6, was used to determine oxidation epitopes in LDL. aOxLDL of IgG and IgM subclass were tested by ELISA against OxLDL. Hypertensive men had increased OxLDL levels compared with normotensives (P = 0.002), whereas autoantibodies tested were largely similar between groups. There was no association between the antibodies tested, or OxLDL and carotid atherosclerosis. Age was not associated with OxLDL or aOxLDL measurements. Taken together, our findings indicate that OxLDL is elevated in hypertensive men, which may predispose to atherosclerosis in hypertension. In contrast, aOxLDL levels were unchanged and the role of aOxLDL may depend on disease stage and/or type. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lipoprotein, oxidized low-density, hypertension, antibody, atherosclerosis
in
Clinical Science
volume
105
issue
5
pages
615 - 620
publisher
Portland Press
external identifiers
  • pmid:12837127
  • wos:000186652600016
  • scopus:0242552697
ISSN
1470-8736
DOI
language
English
LU publication?
yes
id
80aef6dd-a1cc-4b0e-9f7a-df667777c3a8 (old id 295438)
date added to LUP
2007-09-03 09:30:49
date last changed
2018-06-03 03:32:00
@article{80aef6dd-a1cc-4b0e-9f7a-df667777c3a8,
  abstract     = {Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from I I I men with established hypertension (diastolic pressure &gt; 95 mmHg) from the Swedish component of an ongoing hypertension study (European Lacidipine study on Atherosclerosis, ELSA) and from 75 normotensive control men, who were from a Swedish population-screening programme (diastolic pressure &lt; 80 mmHg). The presence of carotid atherosclerosis and the intima-media thicknesses were determined by ultrasonography. A monoclonal antibody to OxLDL, EO6, was used to determine oxidation epitopes in LDL. aOxLDL of IgG and IgM subclass were tested by ELISA against OxLDL. Hypertensive men had increased OxLDL levels compared with normotensives (P = 0.002), whereas autoantibodies tested were largely similar between groups. There was no association between the antibodies tested, or OxLDL and carotid atherosclerosis. Age was not associated with OxLDL or aOxLDL measurements. Taken together, our findings indicate that OxLDL is elevated in hypertensive men, which may predispose to atherosclerosis in hypertension. In contrast, aOxLDL levels were unchanged and the role of aOxLDL may depend on disease stage and/or type.},
  author       = {Frostegard, J and Wu, RH and Lemne, C and Thulin, Thomas and Witztum, JL and De Faire, U},
  issn         = {1470-8736},
  keyword      = {lipoprotein,oxidized low-density,hypertension,antibody,atherosclerosis},
  language     = {eng},
  number       = {5},
  pages        = {615--620},
  publisher    = {Portland Press},
  series       = {Clinical Science},
  title        = {Circulating oxidized low-density lipoprotein is increased in hypertension},
  url          = {http://dx.doi.org/},
  volume       = {105},
  year         = {2003},
}