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Vortex Ring Formation in the Left Ventricle of the Heart: Analysis by 4D Flow MRI and Lagrangian Coherent Structures.

Töger, Johannes LU ; Kanski, Mikael LU ; Carlsson, Marcus LU ; Kovács, Sándor J; Söderlind, Gustaf; Arheden, Håkan LU and Heiberg, Einar LU (2012) In Annals of biomedical engineering 40(12). p.2652-2662
Abstract
Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagrangian Coherent Structures (LCS) is a new flow analysis method, which enables in vivo quantification of vortex ring volume. Therefore, we aimed to investigate if vortex ring volume in the human LV can be reliably quantified using LCS and magnetic resonance velocity mapping (4D PC-MR). Flow velocities were measured using 4D PC-MR in 9 healthy volunteers and 4 patients with dilated ischemic cardiomyopathy. LV LCS were computed... (More)
Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagrangian Coherent Structures (LCS) is a new flow analysis method, which enables in vivo quantification of vortex ring volume. Therefore, we aimed to investigate if vortex ring volume in the human LV can be reliably quantified using LCS and magnetic resonance velocity mapping (4D PC-MR). Flow velocities were measured using 4D PC-MR in 9 healthy volunteers and 4 patients with dilated ischemic cardiomyopathy. LV LCS were computed from flow velocities and manually delineated in all subjects. Vortex volume in the healthy volunteers was 51 ± 6% of the LV volume, and 21 ± 5% in the patients. Interobserver variability was -1 ± 13% and interstudy variability was -2 ± 12%. Compared to idealized flow experiments, the vortex rings showed additional complexity and asymmetry, related to endocardial trabeculation and papillary muscles. In conclusion, LCS and 4D PC-MR enables measurement of vortex ring volume during rapid filling of the LV. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of biomedical engineering
volume
40
issue
12
pages
2652 - 2662
publisher
Springer
external identifiers
  • wos:000311754700018
  • pmid:22805980
  • scopus:84863772491
ISSN
1521-6047
DOI
10.1007/s10439-012-0615-3
language
English
LU publication?
yes
id
799c5069-b138-4832-a881-ca76f34f2c66 (old id 2967015)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22805980?dopt=Abstract
date added to LUP
2012-08-09 20:00:35
date last changed
2017-01-01 05:33:04
@article{799c5069-b138-4832-a881-ca76f34f2c66,
  abstract     = {Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagrangian Coherent Structures (LCS) is a new flow analysis method, which enables in vivo quantification of vortex ring volume. Therefore, we aimed to investigate if vortex ring volume in the human LV can be reliably quantified using LCS and magnetic resonance velocity mapping (4D PC-MR). Flow velocities were measured using 4D PC-MR in 9 healthy volunteers and 4 patients with dilated ischemic cardiomyopathy. LV LCS were computed from flow velocities and manually delineated in all subjects. Vortex volume in the healthy volunteers was 51 ± 6% of the LV volume, and 21 ± 5% in the patients. Interobserver variability was -1 ± 13% and interstudy variability was -2 ± 12%. Compared to idealized flow experiments, the vortex rings showed additional complexity and asymmetry, related to endocardial trabeculation and papillary muscles. In conclusion, LCS and 4D PC-MR enables measurement of vortex ring volume during rapid filling of the LV.},
  author       = {Töger, Johannes and Kanski, Mikael and Carlsson, Marcus and Kovács, Sándor J and Söderlind, Gustaf and Arheden, Håkan and Heiberg, Einar},
  issn         = {1521-6047},
  language     = {eng},
  number       = {12},
  pages        = {2652--2662},
  publisher    = {Springer},
  series       = {Annals of biomedical engineering},
  title        = {Vortex Ring Formation in the Left Ventricle of the Heart: Analysis by 4D Flow MRI and Lagrangian Coherent Structures.},
  url          = {http://dx.doi.org/10.1007/s10439-012-0615-3},
  volume       = {40},
  year         = {2012},
}