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IgG Antibody Response to Toxins A and B in Patients with Clostridium difficile Infection.

Wullt, Marlene LU ; Norén, T; Ljungh, A and Akerlund, T (2012) In Clinical and Vaccine Immunology 19(9). p.1552-1554
Abstract
IgG antibodies against Clostridium difficile toxins A and B were followed in controls and patients with an initial C. difficile infection (CDI). Of the 50 CDI patients, 38 were cured and 12 developed recurrence. Compared to controls, patients had significantly lower anti-toxin A and B IgGs at inclusion, but the subsequent levels rose slightly regardless of clinical outcome. The results imply that the general serum reactivity against toxins A and B in the population reduces the risk of CDI, which suggests implications for vaccine strategies.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Vaccine Immunology
volume
19
issue
9
pages
1552 - 1554
publisher
American Society for Microbiology
external identifiers
  • wos:000308503400029
  • pmid:22787196
  • scopus:84865966570
ISSN
1556-6811
DOI
10.1128/CVI.00210-12
language
English
LU publication?
yes
id
b14d060e-2362-4ded-aeaa-716a398247ad (old id 2967213)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22787196?dopt=Abstract
date added to LUP
2012-08-09 19:04:16
date last changed
2017-08-06 04:44:58
@article{b14d060e-2362-4ded-aeaa-716a398247ad,
  abstract     = {IgG antibodies against Clostridium difficile toxins A and B were followed in controls and patients with an initial C. difficile infection (CDI). Of the 50 CDI patients, 38 were cured and 12 developed recurrence. Compared to controls, patients had significantly lower anti-toxin A and B IgGs at inclusion, but the subsequent levels rose slightly regardless of clinical outcome. The results imply that the general serum reactivity against toxins A and B in the population reduces the risk of CDI, which suggests implications for vaccine strategies.},
  author       = {Wullt, Marlene and Norén, T and Ljungh, A and Akerlund, T},
  issn         = {1556-6811},
  language     = {eng},
  number       = {9},
  pages        = {1552--1554},
  publisher    = {American Society for Microbiology},
  series       = {Clinical and Vaccine Immunology},
  title        = {IgG Antibody Response to Toxins A and B in Patients with Clostridium difficile Infection.},
  url          = {http://dx.doi.org/10.1128/CVI.00210-12},
  volume       = {19},
  year         = {2012},
}