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Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study

Hellman, Urban ; Lejon, Kristina ; Do, Lan ; Geijer, Mats LU ; Baraliakos, Xenofon ; Witte, Torsten and Forsblad-D’Elia, Helena (2025) In Modern Rheumatology 35(1). p.134-143
Abstract

Objectives: There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker patterns in r-axSpA patients concerning disease phenotypes and disease activity. Methods: Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured. Results: Biomarker pattern discriminated... (More)

Objectives: There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker patterns in r-axSpA patients concerning disease phenotypes and disease activity. Methods: Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured. Results: Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-α, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity. Conclusion: Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ankylosing spondylitis, biomarkers, longitudinal observational study, Northern Sweden Health and Disease Study, radiographic axial spondyloarthritis
in
Modern Rheumatology
volume
35
issue
1
pages
10 pages
publisher
Oxford University Press
external identifiers
  • pmid:38706167
  • scopus:85214054667
ISSN
1439-7595
DOI
10.1093/mr/roae039
language
English
LU publication?
yes
id
296ce96c-11aa-4320-8007-ef478177ad9e
date added to LUP
2025-02-24 12:29:54
date last changed
2025-07-29 00:49:19
@article{296ce96c-11aa-4320-8007-ef478177ad9e,
  abstract     = {{<p>Objectives: There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker patterns in r-axSpA patients concerning disease phenotypes and disease activity. Methods: Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured. Results: Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-α, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity. Conclusion: Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease.</p>}},
  author       = {{Hellman, Urban and Lejon, Kristina and Do, Lan and Geijer, Mats and Baraliakos, Xenofon and Witte, Torsten and Forsblad-D’Elia, Helena}},
  issn         = {{1439-7595}},
  keywords     = {{Ankylosing spondylitis; biomarkers; longitudinal observational study; Northern Sweden Health and Disease Study; radiographic axial spondyloarthritis}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{134--143}},
  publisher    = {{Oxford University Press}},
  series       = {{Modern Rheumatology}},
  title        = {{Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study}},
  url          = {{http://dx.doi.org/10.1093/mr/roae039}},
  doi          = {{10.1093/mr/roae039}},
  volume       = {{35}},
  year         = {{2025}},
}