Arthroscopic knee surgery does not modify hyperalgesic responses to heat injury
(2003) In Anesthesiology 99(5). p.1152-1157- Abstract
- Background: Experimental studies suggest that surgical injury may up- or down-regulate nociceptive function. Therefore, the aim of this clinical study was to evaluate the effect of elective arthroscopically assisted knee surgery on nociceptive responses to a heat injury. Methods: Seventeen patients scheduled to undergo repair of the anterior cruciate ligament and 16 healthy controls were studied. The first burn injury was induced 6 days before surgery, and the second burn was induced I day after surgery with a contact thermode (12.5 cm(2), 47degreesC for 7 min) placed on the medial aspect of the calf contralateral to the surgical side. Ibuprofen and acetaminophen were given for 2 days before the first burn injury and again from the time of... (More)
- Background: Experimental studies suggest that surgical injury may up- or down-regulate nociceptive function. Therefore, the aim of this clinical study was to evaluate the effect of elective arthroscopically assisted knee surgery on nociceptive responses to a heat injury. Methods: Seventeen patients scheduled to undergo repair of the anterior cruciate ligament and 16 healthy controls were studied. The first burn injury was induced 6 days before surgery, and the second burn was induced I day after surgery with a contact thermode (12.5 cm(2), 47degreesC for 7 min) placed on the medial aspect of the calf contralateral to the surgical side. Ibuprofen and acetaminophen were given for 2 days before the first burn injury and again from the time of surgery. in the controls, the two burn injuries were separated by 7 days. Sensory variables included cumulated pain score during induction of the burn (visual analog scale), secondary hyperalgesia area, and mechanical and thermal pain perception and pain thresholds assessed before and I h after the burn injury. Results: The heat injuries induced significant increases in pain perception (P < 0.001) and decreases in pain thresholds (P < 0.02). Baseline heat pain thresholds were higher during the second burn injury in patients (P < 0.001) and controls (P < 0.01). However, there were no significant differences in pain to heat injury (P > 0.8), secondary hyperalgesia areas (P > 0.1), mechanical and thermal pain perception (P > 0.1), or mechanical and thermal pain thresholds (P > 0.08) in the burn area before surgery compared to after surgery. Conclusion: Arthroscopic knee surgery did not modify nociceptive responses to a contralaterally applied experimental burn injury. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/297423
- author
- Werner, Mads LU ; Duun, P ; Kraemer, O ; Lassen, B and Kehlet, H
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Anesthesiology
- volume
- 99
- issue
- 5
- pages
- 1152 - 1157
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:14576553
- wos:000186239800022
- scopus:0242332296
- ISSN
- 1528-1175
- language
- English
- LU publication?
- yes
- id
- 6825b933-8db8-4f00-be72-b516f192fa70 (old id 297423)
- alternative location
- http://www.anesthesiology.org/pt/re/anes/abstract.00000542-200311000-00023.htm
- date added to LUP
- 2016-04-01 12:25:15
- date last changed
- 2022-01-27 03:27:32
@article{6825b933-8db8-4f00-be72-b516f192fa70,
abstract = {{Background: Experimental studies suggest that surgical injury may up- or down-regulate nociceptive function. Therefore, the aim of this clinical study was to evaluate the effect of elective arthroscopically assisted knee surgery on nociceptive responses to a heat injury. Methods: Seventeen patients scheduled to undergo repair of the anterior cruciate ligament and 16 healthy controls were studied. The first burn injury was induced 6 days before surgery, and the second burn was induced I day after surgery with a contact thermode (12.5 cm(2), 47degreesC for 7 min) placed on the medial aspect of the calf contralateral to the surgical side. Ibuprofen and acetaminophen were given for 2 days before the first burn injury and again from the time of surgery. in the controls, the two burn injuries were separated by 7 days. Sensory variables included cumulated pain score during induction of the burn (visual analog scale), secondary hyperalgesia area, and mechanical and thermal pain perception and pain thresholds assessed before and I h after the burn injury. Results: The heat injuries induced significant increases in pain perception (P < 0.001) and decreases in pain thresholds (P < 0.02). Baseline heat pain thresholds were higher during the second burn injury in patients (P < 0.001) and controls (P < 0.01). However, there were no significant differences in pain to heat injury (P > 0.8), secondary hyperalgesia areas (P > 0.1), mechanical and thermal pain perception (P > 0.1), or mechanical and thermal pain thresholds (P > 0.08) in the burn area before surgery compared to after surgery. Conclusion: Arthroscopic knee surgery did not modify nociceptive responses to a contralaterally applied experimental burn injury.}},
author = {{Werner, Mads and Duun, P and Kraemer, O and Lassen, B and Kehlet, H}},
issn = {{1528-1175}},
language = {{eng}},
number = {{5}},
pages = {{1152--1157}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Anesthesiology}},
title = {{Arthroscopic knee surgery does not modify hyperalgesic responses to heat injury}},
url = {{http://www.anesthesiology.org/pt/re/anes/abstract.00000542-200311000-00023.htm}},
volume = {{99}},
year = {{2003}},
}