Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions
(2003) In Trends in Genetics 19(10). p.530-536- Abstract
- Nearly half of mammalian genomes are derived from ancient transposable elements (TEs). We analyzed the prevalence of TEs in untranslated regions of human and mouse mRNAs and found evidence suggesting that TEs affect the expression of many genes through the donation of transcriptional regulatory signals. Furthermore, we found that recently expanded gene classes, such as those involved in immunity or response to external stimuli, have transcripts enriched in TEs, whereas TEs are excluded from mRNAs of highly conserved genes with basic functions in development or metabolism. These results support the view that TEs have played a significant role in the diversification and evolution of mammalian genes.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/297480
- author
- van de Lagemaat, LN ; Landry, JR ; Mager, DL and Medstrand, Patrik LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Genetics
- volume
- 19
- issue
- 10
- pages
- 530 - 536
- publisher
- Elsevier
- external identifiers
-
- wos:000186058200003
- pmid:14550626
- scopus:0141561907
- ISSN
- 1362-4555
- DOI
- 10.1016/j.tig.2003.08.004
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Virology (013212007)
- id
- 7ad01224-fa5f-4c6f-823e-6c351c1ba857 (old id 297480)
- date added to LUP
- 2016-04-01 12:13:45
- date last changed
- 2022-03-28 22:02:21
@article{7ad01224-fa5f-4c6f-823e-6c351c1ba857, abstract = {{Nearly half of mammalian genomes are derived from ancient transposable elements (TEs). We analyzed the prevalence of TEs in untranslated regions of human and mouse mRNAs and found evidence suggesting that TEs affect the expression of many genes through the donation of transcriptional regulatory signals. Furthermore, we found that recently expanded gene classes, such as those involved in immunity or response to external stimuli, have transcripts enriched in TEs, whereas TEs are excluded from mRNAs of highly conserved genes with basic functions in development or metabolism. These results support the view that TEs have played a significant role in the diversification and evolution of mammalian genes.}}, author = {{van de Lagemaat, LN and Landry, JR and Mager, DL and Medstrand, Patrik}}, issn = {{1362-4555}}, language = {{eng}}, number = {{10}}, pages = {{530--536}}, publisher = {{Elsevier}}, series = {{Trends in Genetics}}, title = {{Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions}}, url = {{http://dx.doi.org/10.1016/j.tig.2003.08.004}}, doi = {{10.1016/j.tig.2003.08.004}}, volume = {{19}}, year = {{2003}}, }