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Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions

van de Lagemaat, LN; Landry, JR; Mager, DL and Medstrand, Patrik LU (2003) In Trends in Genetics 19(10). p.530-536
Abstract
Nearly half of mammalian genomes are derived from ancient transposable elements (TEs). We analyzed the prevalence of TEs in untranslated regions of human and mouse mRNAs and found evidence suggesting that TEs affect the expression of many genes through the donation of transcriptional regulatory signals. Furthermore, we found that recently expanded gene classes, such as those involved in immunity or response to external stimuli, have transcripts enriched in TEs, whereas TEs are excluded from mRNAs of highly conserved genes with basic functions in development or metabolism. These results support the view that TEs have played a significant role in the diversification and evolution of mammalian genes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Genetics
volume
19
issue
10
pages
530 - 536
publisher
Elsevier
external identifiers
  • wos:000186058200003
  • pmid:14550626
  • scopus:0141561907
ISSN
1362-4555
DOI
10.1016/j.tig.2003.08.004
language
English
LU publication?
yes
id
7ad01224-fa5f-4c6f-823e-6c351c1ba857 (old id 297480)
date added to LUP
2007-09-23 13:32:32
date last changed
2018-02-11 03:30:04
@article{7ad01224-fa5f-4c6f-823e-6c351c1ba857,
  abstract     = {Nearly half of mammalian genomes are derived from ancient transposable elements (TEs). We analyzed the prevalence of TEs in untranslated regions of human and mouse mRNAs and found evidence suggesting that TEs affect the expression of many genes through the donation of transcriptional regulatory signals. Furthermore, we found that recently expanded gene classes, such as those involved in immunity or response to external stimuli, have transcripts enriched in TEs, whereas TEs are excluded from mRNAs of highly conserved genes with basic functions in development or metabolism. These results support the view that TEs have played a significant role in the diversification and evolution of mammalian genes.},
  author       = {van de Lagemaat, LN and Landry, JR and Mager, DL and Medstrand, Patrik},
  issn         = {1362-4555},
  language     = {eng},
  number       = {10},
  pages        = {530--536},
  publisher    = {Elsevier},
  series       = {Trends in Genetics},
  title        = {Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions},
  url          = {http://dx.doi.org/10.1016/j.tig.2003.08.004},
  volume       = {19},
  year         = {2003},
}