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Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo

Jörntell, Henrik LU and Ekerot, Carl-Fredrik LU (2003) In Journal of Neuroscience 23(29). p.9620-9631
Abstract
The cutaneous parallel fiber (PF) receptive fields of cerebellar stellate and basket cells in the cerebellar C3 zone in vivo are normally very small but can be dramatically enlarged by climbing fiber (CF)-dependent plasticity. To analyze the effects of this receptive field plasticity, we present for the first time whole-cell patch-clamp recordings from these interneurons during natural and electrical activation of cutaneously driven synaptic input. In "naive" interneurons, peripheral input nearly exclusively activated a few (two to eight) large PF EPSPs from a specific small skin area that overlapped the receptive field of the local CF input. After conjunctive PF and CF stimulation, numerous small and large EPSPs and ramp-like... (More)
The cutaneous parallel fiber (PF) receptive fields of cerebellar stellate and basket cells in the cerebellar C3 zone in vivo are normally very small but can be dramatically enlarged by climbing fiber (CF)-dependent plasticity. To analyze the effects of this receptive field plasticity, we present for the first time whole-cell patch-clamp recordings from these interneurons during natural and electrical activation of cutaneously driven synaptic input. In "naive" interneurons, peripheral input nearly exclusively activated a few (two to eight) large PF EPSPs from a specific small skin area that overlapped the receptive field of the local CF input. After conjunctive PF and CF stimulation, numerous small and large EPSPs and ramp-like depolarizations could be activated from the entire forelimb skin. These findings therefore confirm previous suggestions that conjunctive PF and CF activation leads to a long-lasting potentiation of PF synaptic input to interneurons. The CF response, which is crucial for the induction of the PF synaptic potentiation, was strong but variable and very different from the conventional EPSPs evoked by PFs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
stellate cells, basket cells, parallel fibers, climbing fibers, cerebellum, plasticity
in
Journal of Neuroscience
volume
23
issue
29
pages
9620 - 9631
publisher
Society for Neuroscience
external identifiers
  • pmid:14573542
  • wos:000186107100016
  • scopus:0142213163
ISSN
1529-2401
language
English
LU publication?
yes
id
abb38e5b-26dc-42fb-abdd-2a07120fa08b (old id 297892)
alternative location
http://www.jneurosci.org/cgi/content/abstract/23/29/9620
date added to LUP
2007-09-13 14:58:07
date last changed
2017-07-30 04:30:22
@article{abb38e5b-26dc-42fb-abdd-2a07120fa08b,
  abstract     = {The cutaneous parallel fiber (PF) receptive fields of cerebellar stellate and basket cells in the cerebellar C3 zone in vivo are normally very small but can be dramatically enlarged by climbing fiber (CF)-dependent plasticity. To analyze the effects of this receptive field plasticity, we present for the first time whole-cell patch-clamp recordings from these interneurons during natural and electrical activation of cutaneously driven synaptic input. In "naive" interneurons, peripheral input nearly exclusively activated a few (two to eight) large PF EPSPs from a specific small skin area that overlapped the receptive field of the local CF input. After conjunctive PF and CF stimulation, numerous small and large EPSPs and ramp-like depolarizations could be activated from the entire forelimb skin. These findings therefore confirm previous suggestions that conjunctive PF and CF activation leads to a long-lasting potentiation of PF synaptic input to interneurons. The CF response, which is crucial for the induction of the PF synaptic potentiation, was strong but variable and very different from the conventional EPSPs evoked by PFs.},
  author       = {Jörntell, Henrik and Ekerot, Carl-Fredrik},
  issn         = {1529-2401},
  keyword      = {stellate cells,basket cells,parallel fibers,climbing fibers,cerebellum,plasticity},
  language     = {eng},
  number       = {29},
  pages        = {9620--9631},
  publisher    = {Society for Neuroscience},
  series       = {Journal of Neuroscience},
  title        = {Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo},
  volume       = {23},
  year         = {2003},
}