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Swedish Lung Cancer Radiation Study Group: Predictive value of age at diagnosis for radiotherapy response in patients with non-small cell lung cancer

Holgersson, Georg; Hoye, Even; Bergqvist, Michael; Ekman, Simon; Nyman, Jan; Helsing, Martin; Friesland, Signe; Holgersson, Margareta; Ekberg, Lars and Blystad, Thomas, et al. (2012) In Acta Oncologica 51(6). p.759-767
Abstract
Introduction. The aim of the present study was to investigate the impact of age at diagnosis on prognosis in patients treated with curatively intended radiotherapy for NSCLC. Material and methods. This is a joint effort among all the Swedish Oncology Departments that includes all identified patients with a diagnosed non-small cell lung cancer that have been subjected to curatively intended irradiation (>= 50 Gy) treated during 1990 to 2000. Included patients had a histopathological/cytological diagnosis date as well as a death date or a last follow-up date. The following variables were studied in relation to overall and disease-specific survival: age, gender, histopathology, time period, smoking status, stage and treatment. Results. The... (More)
Introduction. The aim of the present study was to investigate the impact of age at diagnosis on prognosis in patients treated with curatively intended radiotherapy for NSCLC. Material and methods. This is a joint effort among all the Swedish Oncology Departments that includes all identified patients with a diagnosed non-small cell lung cancer that have been subjected to curatively intended irradiation (>= 50 Gy) treated during 1990 to 2000. Included patients had a histopathological/cytological diagnosis date as well as a death date or a last follow-up date. The following variables were studied in relation to overall and disease-specific survival: age, gender, histopathology, time period, smoking status, stage and treatment. Results. The median overall survival of all 1146 included patients was 14.7 months, while the five-year overall survival rate was 9.5%. Younger patients (<55 years), presented with a more advanced clinical stage but had yet a significantly better overall survival compared with patients in the age groups 55-64 years (p = 0.035) and 65-74 years (p = 0.0097) in a multivariate Cox regression analysis. The overall survival of patients aged >= 75 years was comparable to those aged <55 years. Conclusion. In this large retrospective study we describe that patients younger than 55 years treated with curatively intended radiotherapy for NSCLC have a better overall survival than patients aged 55-64 and 65-74 years and that younger patients seem to benefit more from the addition of surgery and/or chemotherapy to radiotherapy. Due to the exploratory nature of the study, these results should be confirmed in future prospective trials. (Less)
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Acta Oncologica
volume
51
issue
6
pages
759 - 767
publisher
Taylor & Francis
external identifiers
  • wos:000306480600010
  • scopus:84863864404
ISSN
1651-226X
DOI
10.3109/0284186X.2012.681064
language
English
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yes
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893d8989-365e-4f2d-a6de-ed6d534ab83c (old id 2979317)
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2012-09-03 07:16:01
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@article{893d8989-365e-4f2d-a6de-ed6d534ab83c,
  abstract     = {Introduction. The aim of the present study was to investigate the impact of age at diagnosis on prognosis in patients treated with curatively intended radiotherapy for NSCLC. Material and methods. This is a joint effort among all the Swedish Oncology Departments that includes all identified patients with a diagnosed non-small cell lung cancer that have been subjected to curatively intended irradiation (&gt;= 50 Gy) treated during 1990 to 2000. Included patients had a histopathological/cytological diagnosis date as well as a death date or a last follow-up date. The following variables were studied in relation to overall and disease-specific survival: age, gender, histopathology, time period, smoking status, stage and treatment. Results. The median overall survival of all 1146 included patients was 14.7 months, while the five-year overall survival rate was 9.5%. Younger patients (&lt;55 years), presented with a more advanced clinical stage but had yet a significantly better overall survival compared with patients in the age groups 55-64 years (p = 0.035) and 65-74 years (p = 0.0097) in a multivariate Cox regression analysis. The overall survival of patients aged &gt;= 75 years was comparable to those aged &lt;55 years. Conclusion. In this large retrospective study we describe that patients younger than 55 years treated with curatively intended radiotherapy for NSCLC have a better overall survival than patients aged 55-64 and 65-74 years and that younger patients seem to benefit more from the addition of surgery and/or chemotherapy to radiotherapy. Due to the exploratory nature of the study, these results should be confirmed in future prospective trials.},
  author       = {Holgersson, Georg and Hoye, Even and Bergqvist, Michael and Ekman, Simon and Nyman, Jan and Helsing, Martin and Friesland, Signe and Holgersson, Margareta and Ekberg, Lars and Blystad, Thomas and Ewers, Sven-Börje and Morth, Charlotte and Loden, Britta and Henriksson, Roger and Bergstrom, Stefan},
  issn         = {1651-226X},
  language     = {eng},
  number       = {6},
  pages        = {759--767},
  publisher    = {Taylor & Francis},
  series       = {Acta Oncologica},
  title        = {Swedish Lung Cancer Radiation Study Group: Predictive value of age at diagnosis for radiotherapy response in patients with non-small cell lung cancer},
  url          = {http://dx.doi.org/10.3109/0284186X.2012.681064},
  volume       = {51},
  year         = {2012},
}