Advanced

Apoptosis in male germ cells in response to cyclin A1-deficiency and cell cycle arrest

Salazar, G; Liu, D; Liao, Ching LU ; Batkiewicz, L; Arbing, R; Chung, SSW; Lele, K and Wolgemuth, DJ (2003) In Biochemical Pharmacology 66(8). p.1571-1579
Abstract
Male mice homozygous for a mutated allele of the cyclin A 1 gene (Ccna 1) are sterile due to a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1(-1-) spermatocytes is associated with desynapsis abnormalities, lowered MPF activity, and apoptosis as evidenced by TUNEL-positive staining. With time, adult testicular tubules exhibit severe degeneration: some tubules in the older animals are almost devoid of germ cells at various stages of spermatogenesis. The mechanisms by which the cells sense the cell cycle arrest and the regulation of the decision to undergo cell death are under investigation. (C) 2003 Elsevier Inc. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
apoptosis, meiosis, cell cycle, cell death, spermatocytes, germ cells, cyclin A
in
Biochemical Pharmacology
volume
66
issue
8
pages
1571 - 1579
publisher
Elsevier
external identifiers
  • pmid:14555236
  • wos:000186120500034
  • scopus:0642283962
ISSN
0006-2952
DOI
language
English
LU publication?
yes
id
a9ec0276-5c8e-4633-8374-52fafdc81d14 (old id 298116)
date added to LUP
2007-09-21 10:09:55
date last changed
2018-05-29 10:56:37
@article{a9ec0276-5c8e-4633-8374-52fafdc81d14,
  abstract     = {Male mice homozygous for a mutated allele of the cyclin A 1 gene (Ccna 1) are sterile due to a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1(-1-) spermatocytes is associated with desynapsis abnormalities, lowered MPF activity, and apoptosis as evidenced by TUNEL-positive staining. With time, adult testicular tubules exhibit severe degeneration: some tubules in the older animals are almost devoid of germ cells at various stages of spermatogenesis. The mechanisms by which the cells sense the cell cycle arrest and the regulation of the decision to undergo cell death are under investigation. (C) 2003 Elsevier Inc. All rights reserved.},
  author       = {Salazar, G and Liu, D and Liao, Ching and Batkiewicz, L and Arbing, R and Chung, SSW and Lele, K and Wolgemuth, DJ},
  issn         = {0006-2952},
  keyword      = {apoptosis,meiosis,cell cycle,cell death,spermatocytes,germ cells,cyclin A},
  language     = {eng},
  number       = {8},
  pages        = {1571--1579},
  publisher    = {Elsevier},
  series       = {Biochemical Pharmacology},
  title        = {Apoptosis in male germ cells in response to cyclin A1-deficiency and cell cycle arrest},
  url          = {http://dx.doi.org/},
  volume       = {66},
  year         = {2003},
}