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Excretion Rate and Distribution Volumes in Common Marmoset Monkeys After Slow and Fast Injection of Gadobutrol

Helms, Gunther LU orcid ; Schlumbohm, Christina ; Garea Rodriguez, Enrique and Fuchs, Eberhard (2015) ISMRM 23rd Annual Meeting and Exhibition In Proceedings of the ISMRM 23.
Abstract
Common marmoset monkeys (Callithrix jacchus) are increasingly used in models of neurodegenerative diseases. Serial measurements of gadolinium excretion were performed using the dual flip angle method to map R1 on three animals in the wrist coil of a 3T whole-body system. R1 values were analyzed in a ROI in the straight sinus and fitted with a single compartment model. Slow injection of 0.3 mmol Gadovist per kg bodyweight (2 min duration) resulted in faster equilibration and excretion, as well as smaller distribution volumes than fast injection (15 sec). Slow injection and an equilibration delay of 15 minutes are recommended.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Proceedings of the International Society for Magnetic Resonance in Medicine Annual Meeting 2015
series title
Proceedings of the ISMRM
volume
23
article number
3273
pages
1 pages
publisher
International Society for Magnetic Resonance in Medicine
conference name
ISMRM 23rd Annual Meeting and Exhibition
conference location
Toronto, Canada
conference dates
2015-05-30 - 2015-06-05
ISSN
1545-4428
project
Structural brain MRI and SPECT of common marmosets using clinical scanners
language
English
LU publication?
yes
id
298c6b32-586d-45de-9f7e-3809e87a4a43
alternative location
https://index.mirasmart.com/ISMRM2015/PDFfiles/3273.pdf
date added to LUP
2019-06-12 13:08:25
date last changed
2020-08-05 02:19:31
@inproceedings{298c6b32-586d-45de-9f7e-3809e87a4a43,
  abstract     = {{Common marmoset monkeys (Callithrix jacchus) are increasingly used in models of neurodegenerative diseases. Serial measurements of gadolinium excretion were performed using the dual flip angle method to map R1 on three animals in the wrist coil of a 3T whole-body system. R1 values were analyzed in a ROI in the straight sinus and fitted with a single compartment model. Slow injection of 0.3 mmol Gadovist per kg bodyweight (2 min duration) resulted in faster equilibration and excretion, as well as smaller distribution volumes than fast injection (15 sec). Slow injection and an equilibration delay of 15 minutes are recommended.<br/>}},
  author       = {{Helms, Gunther and Schlumbohm, Christina and Garea Rodriguez, Enrique and Fuchs, Eberhard}},
  booktitle    = {{Proceedings of the International Society for Magnetic Resonance in Medicine Annual Meeting 2015}},
  issn         = {{1545-4428}},
  language     = {{eng}},
  month        = {{05}},
  publisher    = {{International Society for Magnetic Resonance in Medicine}},
  series       = {{Proceedings of the ISMRM}},
  title        = {{Excretion Rate and Distribution Volumes in Common Marmoset Monkeys After Slow and Fast Injection of Gadobutrol}},
  url          = {{https://lup.lub.lu.se/search/files/65882178/Helms_ProceedingsISMRM_23_2015_3273.pdf}},
  volume       = {{23}},
  year         = {{2015}},
}