Excretion Rate and Distribution Volumes in Common Marmoset Monkeys After Slow and Fast Injection of Gadobutrol
(2015) ISMRM 23rd Annual Meeting and Exhibition In Proceedings of the ISMRM 23.- Abstract
- Common marmoset monkeys (Callithrix jacchus) are increasingly used in models of neurodegenerative diseases. Serial measurements of gadolinium excretion were performed using the dual flip angle method to map R1 on three animals in the wrist coil of a 3T whole-body system. R1 values were analyzed in a ROI in the straight sinus and fitted with a single compartment model. Slow injection of 0.3 mmol Gadovist per kg bodyweight (2 min duration) resulted in faster equilibration and excretion, as well as smaller distribution volumes than fast injection (15 sec). Slow injection and an equilibration delay of 15 minutes are recommended.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/298c6b32-586d-45de-9f7e-3809e87a4a43
- author
- Helms, Gunther
LU
; Schlumbohm, Christina ; Garea Rodriguez, Enrique and Fuchs, Eberhard
- organization
- publishing date
- 2015-05-30
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Proceedings of the International Society for Magnetic Resonance in Medicine Annual Meeting 2015
- series title
- Proceedings of the ISMRM
- volume
- 23
- article number
- 3273
- pages
- 1 pages
- publisher
- International Society for Magnetic Resonance in Medicine
- conference name
- ISMRM 23rd Annual Meeting and Exhibition
- conference location
- Toronto, Canada
- conference dates
- 2015-05-30 - 2015-06-05
- ISSN
- 1545-4428
- project
- Structural brain MRI and SPECT of common marmosets using clinical scanners
- language
- English
- LU publication?
- yes
- id
- 298c6b32-586d-45de-9f7e-3809e87a4a43
- alternative location
- https://index.mirasmart.com/ISMRM2015/PDFfiles/3273.pdf
- date added to LUP
- 2019-06-12 13:08:25
- date last changed
- 2020-08-05 02:19:31
@inproceedings{298c6b32-586d-45de-9f7e-3809e87a4a43, abstract = {{Common marmoset monkeys (Callithrix jacchus) are increasingly used in models of neurodegenerative diseases. Serial measurements of gadolinium excretion were performed using the dual flip angle method to map R1 on three animals in the wrist coil of a 3T whole-body system. R1 values were analyzed in a ROI in the straight sinus and fitted with a single compartment model. Slow injection of 0.3 mmol Gadovist per kg bodyweight (2 min duration) resulted in faster equilibration and excretion, as well as smaller distribution volumes than fast injection (15 sec). Slow injection and an equilibration delay of 15 minutes are recommended.<br/>}}, author = {{Helms, Gunther and Schlumbohm, Christina and Garea Rodriguez, Enrique and Fuchs, Eberhard}}, booktitle = {{Proceedings of the International Society for Magnetic Resonance in Medicine Annual Meeting 2015}}, issn = {{1545-4428}}, language = {{eng}}, month = {{05}}, publisher = {{International Society for Magnetic Resonance in Medicine}}, series = {{Proceedings of the ISMRM}}, title = {{Excretion Rate and Distribution Volumes in Common Marmoset Monkeys After Slow and Fast Injection of Gadobutrol}}, url = {{https://lup.lub.lu.se/search/files/65882178/Helms_ProceedingsISMRM_23_2015_3273.pdf}}, volume = {{23}}, year = {{2015}}, }