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Associations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes - The Botnia Dietary Study

Ylonen, K; Saloranta, C; Kronberg-Kippila, C; Groop, Leif LU ; Aro, A and Virtanen, SM (2003) In Diabetes Care 26(7). p.1979-1985
Abstract
OBJECTIVE - To study cross-sectional associations of dietary fiber intake with insulin resistance, insulin secretion, and glucose tolerance in a population at high risk for type 2 diabetes. RESEARCH DESIGN AND METHODS - The subjects consisted of 248 male and 304 female adult nondiabetic relatives of patients with type 2 diabetes. Dietary intake was measured by means of two 3-day food records. Associations of total, water-insoluble, and water-soluble fiber with measures of glucose metabolism based on an oral glucose tolerance test, were analyzed by multiple linear regression analysis adjusting for sex, age, length of education, physical activity, BMI, waist-to-hip ratio, systolic blood pressure, and serum triglyceride and HDL cholesterol... (More)
OBJECTIVE - To study cross-sectional associations of dietary fiber intake with insulin resistance, insulin secretion, and glucose tolerance in a population at high risk for type 2 diabetes. RESEARCH DESIGN AND METHODS - The subjects consisted of 248 male and 304 female adult nondiabetic relatives of patients with type 2 diabetes. Dietary intake was measured by means of two 3-day food records. Associations of total, water-insoluble, and water-soluble fiber with measures of glucose metabolism based on an oral glucose tolerance test, were analyzed by multiple linear regression analysis adjusting for sex, age, length of education, physical activity, BMI, waist-to-hip ratio, systolic blood pressure, and serum triglyceride and HDL cholesterol concentrations. The homeostasis model assessment insulin resistance index, the incremental 30-min serum insulin concentration divided by the incremental 30-min glucose concentration, and fasting and 2-h glucose concentrations were the outcome variables. RESULTS - The dietary intake of total as well as water-insoluble and water-soluble fiber was inversely associated with insulin resistance: -0.17 (0.07), P = 0.012; -0.15 (0.07), P = 0.024; and -0.14 (0.07), P = 0.049 [regression coefficients (SE)]. Fiber variables were unrelated to insulin secretion and plasma glucose concentrations. CONCLUSIONS - The results support evidence that a high intake of dietary fiber is associated with enhanced insulin sensitivity and therefore may have a role in the prevention of type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
26
issue
7
pages
1979 - 1985
publisher
American Diabetes Association
external identifiers
  • pmid:12832299
  • wos:000185787600005
  • scopus:17144461665
ISSN
1935-5548
language
English
LU publication?
yes
id
853956d7-e9f2-40f5-ab2c-b0a9512ab2f1 (old id 299437)
alternative location
http://care.diabetesjournals.org/cgi/content/abstract/26/7/1979
date added to LUP
2007-09-24 13:40:52
date last changed
2017-08-06 04:42:27
@article{853956d7-e9f2-40f5-ab2c-b0a9512ab2f1,
  abstract     = {OBJECTIVE - To study cross-sectional associations of dietary fiber intake with insulin resistance, insulin secretion, and glucose tolerance in a population at high risk for type 2 diabetes. RESEARCH DESIGN AND METHODS - The subjects consisted of 248 male and 304 female adult nondiabetic relatives of patients with type 2 diabetes. Dietary intake was measured by means of two 3-day food records. Associations of total, water-insoluble, and water-soluble fiber with measures of glucose metabolism based on an oral glucose tolerance test, were analyzed by multiple linear regression analysis adjusting for sex, age, length of education, physical activity, BMI, waist-to-hip ratio, systolic blood pressure, and serum triglyceride and HDL cholesterol concentrations. The homeostasis model assessment insulin resistance index, the incremental 30-min serum insulin concentration divided by the incremental 30-min glucose concentration, and fasting and 2-h glucose concentrations were the outcome variables. RESULTS - The dietary intake of total as well as water-insoluble and water-soluble fiber was inversely associated with insulin resistance: -0.17 (0.07), P = 0.012; -0.15 (0.07), P = 0.024; and -0.14 (0.07), P = 0.049 [regression coefficients (SE)]. Fiber variables were unrelated to insulin secretion and plasma glucose concentrations. CONCLUSIONS - The results support evidence that a high intake of dietary fiber is associated with enhanced insulin sensitivity and therefore may have a role in the prevention of type 2 diabetes.},
  author       = {Ylonen, K and Saloranta, C and Kronberg-Kippila, C and Groop, Leif and Aro, A and Virtanen, SM},
  issn         = {1935-5548},
  language     = {eng},
  number       = {7},
  pages        = {1979--1985},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Associations of dietary fiber with glucose metabolism in nondiabetic relatives of subjects with type 2 diabetes - The Botnia Dietary Study},
  volume       = {26},
  year         = {2003},
}