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Reversible clustering of sodium channels at the spike is driven by a local crystallization/melting transition around bilayer rafts

Larsson, Marcus LU and Larsson, Kare (2012) In Structural Chemistry 23(4). p.1053-1055
Abstract
The classical theory of nerve signal conduction, introduced half a century ago by Hodgkin and Huxley, was challenged in 2005 by the so called soliton theory introduced by Heimburg and Jackson. This latter theory is based on a bilayer phase transition forming a mechanical wave, involving a transition from a disordered conformation of the bilayer into the gel-state, and the electric pulse is regarded a result of the phase transition. We support the phase transition concept, and provide evidence for a reversible clustering process at the spike. This clustering involves cholesterol-rich rafts, where the voltage-gated sodium channels are located of the sodium channels at the spike region. The clustering is driven by local crystallization into... (More)
The classical theory of nerve signal conduction, introduced half a century ago by Hodgkin and Huxley, was challenged in 2005 by the so called soliton theory introduced by Heimburg and Jackson. This latter theory is based on a bilayer phase transition forming a mechanical wave, involving a transition from a disordered conformation of the bilayer into the gel-state, and the electric pulse is regarded a result of the phase transition. We support the phase transition concept, and provide evidence for a reversible clustering process at the spike. This clustering involves cholesterol-rich rafts, where the voltage-gated sodium channels are located of the sodium channels at the spike region. The clustering is driven by local crystallization into the gel-type of bilayer conformation around the rafts, and is explained by the hexagonal chain organization in the gel-phase related to that in the raft structure. The clustering is reversed at the melting transition, and the role of the action potential in these phase transition is finally considered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Nerve signal, Phase transition, Soliton theory, Cholesterol segregation, Lipid rafts, Raft clustering, Bilayer crystallization, Sodium channel, clustering
in
Structural Chemistry
volume
23
issue
4
pages
1053 - 1055
publisher
Springer
external identifiers
  • wos:000306215300010
  • scopus:84867232171
ISSN
1040-0400
DOI
10.1007/s11224-011-9875-z
language
English
LU publication?
yes
id
45326413-b9d0-4a2c-9aef-60a379b690ae (old id 2994963)
date added to LUP
2012-09-03 07:17:53
date last changed
2017-08-27 03:22:20
@article{45326413-b9d0-4a2c-9aef-60a379b690ae,
  abstract     = {The classical theory of nerve signal conduction, introduced half a century ago by Hodgkin and Huxley, was challenged in 2005 by the so called soliton theory introduced by Heimburg and Jackson. This latter theory is based on a bilayer phase transition forming a mechanical wave, involving a transition from a disordered conformation of the bilayer into the gel-state, and the electric pulse is regarded a result of the phase transition. We support the phase transition concept, and provide evidence for a reversible clustering process at the spike. This clustering involves cholesterol-rich rafts, where the voltage-gated sodium channels are located of the sodium channels at the spike region. The clustering is driven by local crystallization into the gel-type of bilayer conformation around the rafts, and is explained by the hexagonal chain organization in the gel-phase related to that in the raft structure. The clustering is reversed at the melting transition, and the role of the action potential in these phase transition is finally considered.},
  author       = {Larsson, Marcus and Larsson, Kare},
  issn         = {1040-0400},
  keyword      = {Nerve signal,Phase transition,Soliton theory,Cholesterol segregation,Lipid rafts,Raft clustering,Bilayer crystallization,Sodium channel,clustering},
  language     = {eng},
  number       = {4},
  pages        = {1053--1055},
  publisher    = {Springer},
  series       = {Structural Chemistry},
  title        = {Reversible clustering of sodium channels at the spike is driven by a local crystallization/melting transition around bilayer rafts},
  url          = {http://dx.doi.org/10.1007/s11224-011-9875-z},
  volume       = {23},
  year         = {2012},
}