Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus
(2020) In Trends in Molecular Medicine 26(3). p.285-295- Abstract
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia–lymphatic (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-supported perivascular channels. Human studies have implicated impaired glymphatic function in both AD and iNPH. Continued investigation into the role of glymphatic system biology in AD and iNPH models could lead to new strategies to improve brain... (More)
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia–lymphatic (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-supported perivascular channels. Human studies have implicated impaired glymphatic function in both AD and iNPH. Continued investigation into the role of glymphatic system biology in AD and iNPH models could lead to new strategies to improve brain health by restoring homeostatic brain metabolism and CSF dynamics.
(Less)
- author
- Reeves, Benjamin C. ; Karimy, Jason K. ; Kundishora, Adam J. ; Mestre, Humberto ; Cerci, H. Mert ; Matouk, Charles ; Alper, Seth L. ; Lundgaard, Iben LU ; Nedergaard, Maiken and Kahle, Kristopher T.
- organization
- publishing date
- 2020-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aging, Alzheimer's disease, dementia, glial-lymphatic, glymphatic, hydrocephalus, idiopathic normal pressure hydrocephalus
- in
- Trends in Molecular Medicine
- volume
- 26
- issue
- 3
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85077932270
- pmid:31959516
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2019.11.008
- language
- English
- LU publication?
- yes
- id
- 299f3cd7-1e84-460f-8928-66d405753c4f
- date added to LUP
- 2020-01-30 14:29:38
- date last changed
- 2024-06-13 10:35:49
@article{299f3cd7-1e84-460f-8928-66d405753c4f, abstract = {{<p>Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4). The glia–lymphatic (glymphatic) system facilitates brain fluid clearance and waste removal during sleep via glia-supported perivascular channels. Human studies have implicated impaired glymphatic function in both AD and iNPH. Continued investigation into the role of glymphatic system biology in AD and iNPH models could lead to new strategies to improve brain health by restoring homeostatic brain metabolism and CSF dynamics.</p>}}, author = {{Reeves, Benjamin C. and Karimy, Jason K. and Kundishora, Adam J. and Mestre, Humberto and Cerci, H. Mert and Matouk, Charles and Alper, Seth L. and Lundgaard, Iben and Nedergaard, Maiken and Kahle, Kristopher T.}}, issn = {{1471-4914}}, keywords = {{aging; Alzheimer's disease; dementia; glial-lymphatic; glymphatic; hydrocephalus; idiopathic normal pressure hydrocephalus}}, language = {{eng}}, month = {{03}}, number = {{3}}, pages = {{285--295}}, publisher = {{Elsevier}}, series = {{Trends in Molecular Medicine}}, title = {{Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus}}, url = {{http://dx.doi.org/10.1016/j.molmed.2019.11.008}}, doi = {{10.1016/j.molmed.2019.11.008}}, volume = {{26}}, year = {{2020}}, }