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Dementia prevention in memory clinics : recommendations from the European task force for brain health services

Frisoni, Giovanni B. ; Altomare, Daniele ; Ribaldi, Federica ; Villain, Nicolas ; Brayne, Carol ; Mukadam, Naaheed ; Abramowicz, Marc ; Barkhof, Frederik ; Berthier, Marcelo and Bieler-Aeschlimann, Melanie , et al. (2023) In The Lancet Regional Health - Europe 26.
Abstract

Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk... (More)

Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cognitive enhancement, Dementia, Memory clinic, Prevention, Risk assessment, Risk communication, Risk reduction
in
The Lancet Regional Health - Europe
volume
26
article number
100576
publisher
Elsevier
external identifiers
  • scopus:85148701592
  • pmid:36895446
ISSN
2666-7762
DOI
10.1016/j.lanepe.2022.100576
language
English
LU publication?
yes
id
29a453b3-16ec-4c42-861e-b66ed2496f70
date added to LUP
2023-03-15 12:15:02
date last changed
2024-02-16 10:13:19
@article{29a453b3-16ec-4c42-861e-b66ed2496f70,
  abstract     = {{<p>Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.</p>}},
  author       = {{Frisoni, Giovanni B. and Altomare, Daniele and Ribaldi, Federica and Villain, Nicolas and Brayne, Carol and Mukadam, Naaheed and Abramowicz, Marc and Barkhof, Frederik and Berthier, Marcelo and Bieler-Aeschlimann, Melanie and Blennow, Kaj and Brioschi Guevara, Andrea and Carrera, Emmanuel and Chételat, Gaël and Csajka, Chantal and Demonet, Jean François and Dodich, Alessandra and Garibotto, Valentina and Georges, Jean and Hurst, Samia and Jessen, Frank and Kivipelto, Miia and Llewellyn, David J. and McWhirter, Laura and Milne, Richard and Minguillón, Carolina and Miniussi, Carlo and Molinuevo, José Luis and Nilsson, Peter M. and Noyce, Alastair and Ranson, Janice M. and Grau-Rivera, Oriol and Schott, Jonathan M. and Solomon, Alina and Stephen, Ruth and van der Flier, Wiesje and van Duijn, Cornelia and Vellas, Bruno and Visser, Leonie N.C. and Cummings, Jeffrey L. and Scheltens, Philip and Ritchie, Craig and Dubois, Bruno}},
  issn         = {{2666-7762}},
  keywords     = {{Cognitive enhancement; Dementia; Memory clinic; Prevention; Risk assessment; Risk communication; Risk reduction}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{The Lancet Regional Health - Europe}},
  title        = {{Dementia prevention in memory clinics : recommendations from the European task force for brain health services}},
  url          = {{http://dx.doi.org/10.1016/j.lanepe.2022.100576}},
  doi          = {{10.1016/j.lanepe.2022.100576}},
  volume       = {{26}},
  year         = {{2023}},
}