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Regulation of placental transfer : The Na+/H+ exchanger - A review

Sibley, C. P.; Glazier, J. D.; Greenwood, Sarah L.; Lacey, J Hubert; Mynett, K.; Speake, P.; Jansson, T.; Johansson, Martin LU and Powell, T. L. (2002) In Placenta 23(SUPPL. 1). p.39-46
Abstract

This review article considers the purposes and mechanisms of regulation of placental transfer in general terms and then illustrates some key points with reference to the Na+/H+ exchanger (NHE), a transport protein found in the syncytiotrophoblast. NHE probably has a role in the homeostasis of syncytiotrophoblast intracellular pH and may also be involved in syncytiotrophoblast cell volume regulation as well as H+ loss from and Na+ transfer to the fetus. The activity and expression of NHE in the microvillous plasma membrane of the syncytiotrophoblast is reduced in placentas from preterm, growth restricted babies as compared to their gestationally matched normally grown counterparts. There are... (More)

This review article considers the purposes and mechanisms of regulation of placental transfer in general terms and then illustrates some key points with reference to the Na+/H+ exchanger (NHE), a transport protein found in the syncytiotrophoblast. NHE probably has a role in the homeostasis of syncytiotrophoblast intracellular pH and may also be involved in syncytiotrophoblast cell volume regulation as well as H+ loss from and Na+ transfer to the fetus. The activity and expression of NHE in the microvillous plasma membrane of the syncytiotrophoblast is reduced in placentas from preterm, growth restricted babies as compared to their gestationally matched normally grown counterparts. There are differential effects of gestation in normal pregnancy on NHE mRNA, NHE protein and NHE activity. There is also evidence of acute modulation of NHE activity. Regulation of NHE in syncytiotrophoblast is therefore complex with control at transcription, post transcription and post translational loci.

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author
publishing date
type
Contribution to journal
publication status
published
in
Placenta
volume
23
issue
SUPPL. 1
pages
39 - 46
publisher
W B Saunders
external identifiers
  • scopus:10644220232
ISSN
0143-4004
DOI
10.1053/plac.2002.0790
language
English
LU publication?
no
id
29aceb9b-0bce-484d-a573-6148107aa66e
date added to LUP
2017-04-10 16:39:32
date last changed
2017-11-05 05:16:05
@article{29aceb9b-0bce-484d-a573-6148107aa66e,
  abstract     = {<p>This review article considers the purposes and mechanisms of regulation of placental transfer in general terms and then illustrates some key points with reference to the Na<sup>+</sup>/H<sup>+</sup> exchanger (NHE), a transport protein found in the syncytiotrophoblast. NHE probably has a role in the homeostasis of syncytiotrophoblast intracellular pH and may also be involved in syncytiotrophoblast cell volume regulation as well as H<sup>+</sup> loss from and Na<sup>+</sup> transfer to the fetus. The activity and expression of NHE in the microvillous plasma membrane of the syncytiotrophoblast is reduced in placentas from preterm, growth restricted babies as compared to their gestationally matched normally grown counterparts. There are differential effects of gestation in normal pregnancy on NHE mRNA, NHE protein and NHE activity. There is also evidence of acute modulation of NHE activity. Regulation of NHE in syncytiotrophoblast is therefore complex with control at transcription, post transcription and post translational loci.</p>},
  author       = {Sibley, C. P. and Glazier, J. D. and Greenwood, Sarah L. and Lacey, J Hubert and Mynett, K. and Speake, P. and Jansson, T. and Johansson, Martin and Powell, T. L.},
  issn         = {0143-4004},
  language     = {eng},
  number       = {SUPPL. 1},
  pages        = {39--46},
  publisher    = {W B Saunders},
  series       = {Placenta},
  title        = {Regulation of placental transfer : The Na<sup>+</sup>/H<sup>+</sup> exchanger - A review},
  url          = {http://dx.doi.org/10.1053/plac.2002.0790},
  volume       = {23},
  year         = {2002},
}