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International Multidisciplinary Consensus Report on Definitions, Diagnostic Criteria, and Management of Fatty Pancreas : A Joint Statement Endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG

Vujasinovic, Miroslav ; Demir, Ihsan Ekin ; Marchegiani, Giovanni ; Hegyi, Peter ; Archibugi, Livia ; Valente, Roberto ; Capurso, Gabriele ; Witt, Heiko ; Bonovas, Stefanos and Piovani, Daniele , et al. (2026) In United European Gastroenterology Journal 14(1). p.70185-70185
Abstract

This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reporting and clinical communication. Another major contribution of the report is the consensus on diagnostic imaging findings, which was based on radiological and endoscopic modalities. The proposed criteria aim to enhance consistency in clinical assessment and support the development of standardized research protocols. In addition to establishing... (More)

This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reporting and clinical communication. Another major contribution of the report is the consensus on diagnostic imaging findings, which was based on radiological and endoscopic modalities. The proposed criteria aim to enhance consistency in clinical assessment and support the development of standardized research protocols. In addition to establishing terminology and diagnostic frameworks, the report also synthesizes current knowledge across a wide range of relevant domains. These include the etiology and epidemiology of fatty pancreas, as well as its associations with alcohol consumption, smoking, acute and chronic pancreatitis, pancreatic exocrine insufficiency, type 2 diabetes mellitus, and surgical outcomes. The potential links between fatty pancreas and neoplastic conditions such as intraductal papillary mucinous neoplasms and pancreatic cancer are also addressed, alongside the current understanding of its metabolic implications (beta-cell function and glucose homeostasis) and treatment strategies. Throughout the consensus process, a consistent theme emerged: the limited availability of high-quality, prospective clinical data. Therefore, many of the recommendations in this report are based on expert consensus rather than strong empirical evidence. As such, the statements require rigorous prospective validation before they can be adopted into routine clinical practice. This underscores a critical need for further research, particularly studies aimed at clarifying causal relationships, validating diagnostic tools, and determining the clinical relevance of fatty pancreas across diverse patient populations. This report serves as both a summary of our current understanding and a roadmap for future investigations, aiming to close existing knowledge gaps and guide evidence-based clinical practice in this emerging field.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Pancreatic Diseases/diagnosis, Pancreas/pathology, Terminology as Topic, Pancreatic Neoplasms/diagnosis, Adipose Tissue/pathology, Diabetes Mellitus, Type 2/complications
in
United European Gastroenterology Journal
volume
14
issue
1
pages
70185 - 70185
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:105030218820
  • pmid:41689768
ISSN
2050-6406
DOI
10.1002/ueg2.70185
language
English
LU publication?
yes
additional info
© 2026 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.
id
29ad8832-5e9c-4a25-8794-54db1992da86
date added to LUP
2026-05-18 11:38:11
date last changed
2026-07-07 12:54:15
@article{29ad8832-5e9c-4a25-8794-54db1992da86,
  abstract     = {{<p>This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reporting and clinical communication. Another major contribution of the report is the consensus on diagnostic imaging findings, which was based on radiological and endoscopic modalities. The proposed criteria aim to enhance consistency in clinical assessment and support the development of standardized research protocols. In addition to establishing terminology and diagnostic frameworks, the report also synthesizes current knowledge across a wide range of relevant domains. These include the etiology and epidemiology of fatty pancreas, as well as its associations with alcohol consumption, smoking, acute and chronic pancreatitis, pancreatic exocrine insufficiency, type 2 diabetes mellitus, and surgical outcomes. The potential links between fatty pancreas and neoplastic conditions such as intraductal papillary mucinous neoplasms and pancreatic cancer are also addressed, alongside the current understanding of its metabolic implications (beta-cell function and glucose homeostasis) and treatment strategies. Throughout the consensus process, a consistent theme emerged: the limited availability of high-quality, prospective clinical data. Therefore, many of the recommendations in this report are based on expert consensus rather than strong empirical evidence. As such, the statements require rigorous prospective validation before they can be adopted into routine clinical practice. This underscores a critical need for further research, particularly studies aimed at clarifying causal relationships, validating diagnostic tools, and determining the clinical relevance of fatty pancreas across diverse patient populations. This report serves as both a summary of our current understanding and a roadmap for future investigations, aiming to close existing knowledge gaps and guide evidence-based clinical practice in this emerging field.</p>}},
  author       = {{Vujasinovic, Miroslav and Demir, Ihsan Ekin and Marchegiani, Giovanni and Hegyi, Peter and Archibugi, Livia and Valente, Roberto and Capurso, Gabriele and Witt, Heiko and Bonovas, Stefanos and Piovani, Daniele and Rosendahl, Jonas and Maisonneuve, Patrick and Verbeke, Caroline S and Karçaaltıncaba, Muşturay and Dominguez-Muñoz, J Enrique and Scheers, Isabelle and Czako, Laszlo and Wagner, Robert and Rebours, Vinciane and Öhlund, Daniel and Idilman, Ilkay S and Overbeek, Kasper and Gubergrits, Natalya and Engjom, Trond and Neesse, Albrecht and Apte, Minoti and Bezmarević, Mihailo and Braren, Rickmer and Bunduc, Stefania and Ceyhan, Güralp Onur and Chouhan, Manil Dinesh and Couvelard, Anne and Cros, Jérôme and Iglesia, Daniel de la and de-Madaria, Enrique and Drenth, Joost P H and Drewes, Asbjørn Mohr and Sarasqueta, Arantza Fariña and Fracasso, Pierluigi and Francque, Sven and Frøkjær, Jens Brøndum and Iglesias-Garcia, Julio and Garg, Pramod and Gerst, Felicia and Gulbinas, Antanas and Gürcinar, Ibrahim Halil and Heni, Martin and Hyun, Jong Jin and Jonas, Eduard and Kiriukova, Mariia and Kitano, Masayuki and Krag, Aleksander and Laukkarinen, Johanna and Lipp, Mónika and Lovecek, Martin and Martignoni, Marc and Masip, Etna and Matsumoto, Ryotaro and Molven, Anders and Mozhyna, Tetiana and Nosakova, Lenka and Obmann, Verena and Ockenga, Johann and Pandanaboyana, Sanjay and Panić, Nikola and Papachristou, Georgios and Pasqua, Analia Verónica and Pawlak, Katarzyna M and Pelaez-Luna, Mario and Regel, Ivonne and Regnér, Sara and Robinson, Stuart and Seicean, Andrada and Singh, Vijay and Smits, Mark M and Sung, Min Je and Tacelli, Matteo and Taylor, Roy and Teutsch, Brigitta and Udrescu, Mihaela and Wilschanski, Michael and Yavas, Aslihan and Zamboni, Giulia A and Löhr, J Matthias}},
  issn         = {{2050-6406}},
  keywords     = {{Humans; Pancreatic Diseases/diagnosis; Pancreas/pathology; Terminology as Topic; Pancreatic Neoplasms/diagnosis; Adipose Tissue/pathology; Diabetes Mellitus, Type 2/complications}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{70185--70185}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{United European Gastroenterology Journal}},
  title        = {{International Multidisciplinary Consensus Report on Definitions, Diagnostic Criteria, and Management of Fatty Pancreas : A Joint Statement Endorsed by EPC, APA, EASD, EASL, ESGAR, ESGE, ESP, ESPCG, ESPEN, ESPGHAN, IAP, JPS, KPBA, LAPSG, and UEG}},
  url          = {{http://dx.doi.org/10.1002/ueg2.70185}},
  doi          = {{10.1002/ueg2.70185}},
  volume       = {{14}},
  year         = {{2026}},
}