Advanced

Meningioma growth dynamics assessed by radiocarbon retrospective birth dating

Huttner, Hagen B.; Bergmann, Olaf LU ; Salehpour, Mehran; El Cheikh, Raouf; Nakamura, Makoto; Tortora, Angelo; Heinke, Paula; Coras, Roland; Englund, Elisabet LU and Eyüpoglu, Ilker Y., et al. (2017) In EBioMedicine
Abstract

It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum, are usually benign and considered slowly growing. There is an intense debate regarding their age and growth pattern and when meningiomas should be resected. We have assessed the age and growth dynamics of 14 patients with meningiomas (WHO grade I: n=6 with meningothelial and n=6 with fibrous subtype, as well as n=2 atypical WHO grade II meningiomas) by combining retrospective birth-dating of cells by analyzing incorporation of nuclear-bomb-test-derived 14C, analysis of cell... (More)

It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum, are usually benign and considered slowly growing. There is an intense debate regarding their age and growth pattern and when meningiomas should be resected. We have assessed the age and growth dynamics of 14 patients with meningiomas (WHO grade I: n=6 with meningothelial and n=6 with fibrous subtype, as well as n=2 atypical WHO grade II meningiomas) by combining retrospective birth-dating of cells by analyzing incorporation of nuclear-bomb-test-derived 14C, analysis of cell proliferation, cell density, MRI imaging and mathematical modeling. We provide an integrated model of the growth dynamics of benign meningiomas. The mean age of WHO grade I meningiomas was 22.1±6.5years, whereas atypical WHO grade II meningiomas originated 1.5±0.1years prior to surgery (p<0.01). We conclude that WHO grade I meningiomas are very slowly growing brain tumors, which are resected in average two decades after time of origination.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
C14, Meningioma, Radiocarbon, Tumor growth
in
EBioMedicine
publisher
Elsevier
external identifiers
  • scopus:85038816984
ISSN
2352-3964
DOI
10.1016/j.ebiom.2017.12.020
language
English
LU publication?
no
id
29b415ad-f5b8-4c3d-b441-6a10787195f0
date added to LUP
2018-01-05 07:48:02
date last changed
2018-01-06 03:00:09
@article{29b415ad-f5b8-4c3d-b441-6a10787195f0,
  abstract     = {<p>It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum, are usually benign and considered slowly growing. There is an intense debate regarding their age and growth pattern and when meningiomas should be resected. We have assessed the age and growth dynamics of 14 patients with meningiomas (WHO grade I: n=6 with meningothelial and n=6 with fibrous subtype, as well as n=2 atypical WHO grade II meningiomas) by combining retrospective birth-dating of cells by analyzing incorporation of nuclear-bomb-test-derived <sup>14</sup>C, analysis of cell proliferation, cell density, MRI imaging and mathematical modeling. We provide an integrated model of the growth dynamics of benign meningiomas. The mean age of WHO grade I meningiomas was 22.1±6.5years, whereas atypical WHO grade II meningiomas originated 1.5±0.1years prior to surgery (p&lt;0.01). We conclude that WHO grade I meningiomas are very slowly growing brain tumors, which are resected in average two decades after time of origination.</p>},
  author       = {Huttner, Hagen B. and Bergmann, Olaf and Salehpour, Mehran and El Cheikh, Raouf and Nakamura, Makoto and Tortora, Angelo and Heinke, Paula and Coras, Roland and Englund, Elisabet and Eyüpoglu, Ilker Y. and Kuramatsu, Joji B. and Roeder, Sebastian S. and Kloska, Stephan P. and Muehlen, Iris and Doerfler, Arnd and Schwab, Stefan and Possnert, Göran and Bernard, Samuel and Frisén, Jonas},
  issn         = {2352-3964},
  keyword      = {C14,Meningioma,Radiocarbon,Tumor growth},
  language     = {eng},
  month        = {12},
  publisher    = {Elsevier},
  series       = {EBioMedicine},
  title        = {Meningioma growth dynamics assessed by radiocarbon retrospective birth dating},
  url          = {http://dx.doi.org/10.1016/j.ebiom.2017.12.020},
  year         = {2017},
}