Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis
Liu, Yingchun LU and Ringnér, Markus LU
(2007)
In Genome Biology
8(5).
- Abstract
- Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation result in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/651074
- author
- Liu, Yingchun
LU
and Ringnér, Markus
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genome Biology
- volume
- 8
- issue
- 5
- article number
- R77
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000246983100028
- scopus:34548813411
- ISSN
- 1474-7596
- DOI
- 10.1186/gb-2007-8-5-r77
- language
- English
- LU publication?
- yes
- id
- 29de0fb3-073b-4d66-b1fd-d4fad4a5bdc6 (old id 651074)
- date added to LUP
- 2016-04-01 11:57:43
- date last changed
- 2024-01-08 03:00:05
@article{29de0fb3-073b-4d66-b1fd-d4fad4a5bdc6,
abstract = {{Gene expression signatures consisting of tens to hundreds of genes have been found to be informative for different biological states. Recently, many computational methods have been proposed for biological interpretation of such signatures. However, there is a lack of methods for identifying cell signaling pathways whose deregulation result in an observed expression signature. We present a strategy for identifying such signaling pathways and evaluate the strategy using six human and mouse gene expression signatures.}},
author = {{Liu, Yingchun and Ringnér, Markus}},
issn = {{1474-7596}},
language = {{eng}},
number = {{5}},
publisher = {{BioMed Central (BMC)}},
series = {{Genome Biology}},
title = {{Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis}},
url = {{http://dx.doi.org/10.1186/gb-2007-8-5-r77}},
doi = {{10.1186/gb-2007-8-5-r77}},
volume = {{8}},
year = {{2007}},
}