Advanced

Natural corollaries and recovery after acute ACL injury : The NACOX cohort study protocol

Kvist, Joanna ; Gauffin, Håkan ; Tigerstrand Grevnerts, Hanna ; Ardern, Clare ; Hägglund, Martin ; Stålman, Anders and Frobell, Richard LU (2018) In BMJ Open 8(6).
Abstract

Introduction Anterior cruciate ligament (ACL) injury can result in joint instability, decreased functional performance, reduced physical activity and quality of life and an increased risk for post-traumatic osteoarthritis. Despite the development of new treatment techniques and extensive research, the complex and multifaceted nature of ACL injury and its consequences are yet to be fully understood. The overall aim of the NACOX study is to evaluate the natural corollaries and recovery after an ACL injury. Methods and analysis The NACOX study is a multicentre prospective prognostic cohort study of patients with acute ACL injury. At seven sites in Sweden, we will include patients aged 15-40 years, within 6 weeks after primary ACL injury.... (More)

Introduction Anterior cruciate ligament (ACL) injury can result in joint instability, decreased functional performance, reduced physical activity and quality of life and an increased risk for post-traumatic osteoarthritis. Despite the development of new treatment techniques and extensive research, the complex and multifaceted nature of ACL injury and its consequences are yet to be fully understood. The overall aim of the NACOX study is to evaluate the natural corollaries and recovery after an ACL injury. Methods and analysis The NACOX study is a multicentre prospective prognostic cohort study of patients with acute ACL injury. At seven sites in Sweden, we will include patients aged 15-40 years, within 6 weeks after primary ACL injury. Patients will complete questionnaires at multiple occasions over the 3 years following injury or the 3 years following ACL reconstruction (for participants who have surgical treatment). In addition, a subgroup of 130 patients will be followed with clinical examinations, several imaging modalities and biological samples. Data analyses will be specific to each aim. Ethics and dissemination This study has been approved by the regional Ethical committee in Linköping, Sweden (Dnr 2016/44-31 and 2017/221-32). We plan to present the results at national and international conferences and in peer-reviewed scientific journals. Participants will receive a short summary of the results following completion of the study. Trial registration number NCT02931084.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
knee, magnetic resonance imaging, musculoskeletal disorders, sports medicine
in
BMJ Open
volume
8
issue
6
article number
e020543
publisher
BMJ Publishing Group
external identifiers
  • scopus:85049129209
  • pmid:29950463
ISSN
2044-6055
DOI
10.1136/bmjopen-2017-020543
language
English
LU publication?
yes
id
29dea83c-a132-455a-9130-f3b0e72d95bc
date added to LUP
2018-07-17 09:24:12
date last changed
2021-03-03 01:14:44
@article{29dea83c-a132-455a-9130-f3b0e72d95bc,
  abstract     = {<p>Introduction Anterior cruciate ligament (ACL) injury can result in joint instability, decreased functional performance, reduced physical activity and quality of life and an increased risk for post-traumatic osteoarthritis. Despite the development of new treatment techniques and extensive research, the complex and multifaceted nature of ACL injury and its consequences are yet to be fully understood. The overall aim of the NACOX study is to evaluate the natural corollaries and recovery after an ACL injury. Methods and analysis The NACOX study is a multicentre prospective prognostic cohort study of patients with acute ACL injury. At seven sites in Sweden, we will include patients aged 15-40 years, within 6 weeks after primary ACL injury. Patients will complete questionnaires at multiple occasions over the 3 years following injury or the 3 years following ACL reconstruction (for participants who have surgical treatment). In addition, a subgroup of 130 patients will be followed with clinical examinations, several imaging modalities and biological samples. Data analyses will be specific to each aim. Ethics and dissemination This study has been approved by the regional Ethical committee in Linköping, Sweden (Dnr 2016/44-31 and 2017/221-32). We plan to present the results at national and international conferences and in peer-reviewed scientific journals. Participants will receive a short summary of the results following completion of the study. Trial registration number NCT02931084.</p>},
  author       = {Kvist, Joanna and Gauffin, Håkan and Tigerstrand Grevnerts, Hanna and Ardern, Clare and Hägglund, Martin and Stålman, Anders and Frobell, Richard},
  issn         = {2044-6055},
  language     = {eng},
  month        = {06},
  number       = {6},
  publisher    = {BMJ Publishing Group},
  series       = {BMJ Open},
  title        = {Natural corollaries and recovery after acute ACL injury : The NACOX cohort study protocol},
  url          = {http://dx.doi.org/10.1136/bmjopen-2017-020543},
  doi          = {10.1136/bmjopen-2017-020543},
  volume       = {8},
  year         = {2018},
}