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Natural corollaries and recovery after acute ACL injury : The NACOX cohort study protocol

Kvist, Joanna; Gauffin, Håkan; Tigerstrand Grevnerts, Hanna; Ardern, Clare; Hägglund, Martin; Stålman, Anders and Frobell, Richard LU (2018) In BMJ Open 8(6).
Abstract

Introduction Anterior cruciate ligament (ACL) injury can result in joint instability, decreased functional performance, reduced physical activity and quality of life and an increased risk for post-traumatic osteoarthritis. Despite the development of new treatment techniques and extensive research, the complex and multifaceted nature of ACL injury and its consequences are yet to be fully understood. The overall aim of the NACOX study is to evaluate the natural corollaries and recovery after an ACL injury. Methods and analysis The NACOX study is a multicentre prospective prognostic cohort study of patients with acute ACL injury. At seven sites in Sweden, we will include patients aged 15-40 years, within 6 weeks after primary ACL injury.... (More)

Introduction Anterior cruciate ligament (ACL) injury can result in joint instability, decreased functional performance, reduced physical activity and quality of life and an increased risk for post-traumatic osteoarthritis. Despite the development of new treatment techniques and extensive research, the complex and multifaceted nature of ACL injury and its consequences are yet to be fully understood. The overall aim of the NACOX study is to evaluate the natural corollaries and recovery after an ACL injury. Methods and analysis The NACOX study is a multicentre prospective prognostic cohort study of patients with acute ACL injury. At seven sites in Sweden, we will include patients aged 15-40 years, within 6 weeks after primary ACL injury. Patients will complete questionnaires at multiple occasions over the 3 years following injury or the 3 years following ACL reconstruction (for participants who have surgical treatment). In addition, a subgroup of 130 patients will be followed with clinical examinations, several imaging modalities and biological samples. Data analyses will be specific to each aim. Ethics and dissemination This study has been approved by the regional Ethical committee in Linköping, Sweden (Dnr 2016/44-31 and 2017/221-32). We plan to present the results at national and international conferences and in peer-reviewed scientific journals. Participants will receive a short summary of the results following completion of the study. Trial registration number NCT02931084.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
knee, magnetic resonance imaging, musculoskeletal disorders, sports medicine
in
BMJ Open
volume
8
issue
6
publisher
British Medical Journal Publishing Group
external identifiers
  • scopus:85049129209
ISSN
2044-6055
DOI
10.1136/bmjopen-2017-020543
language
English
LU publication?
yes
id
29dea83c-a132-455a-9130-f3b0e72d95bc
date added to LUP
2018-07-17 09:24:12
date last changed
2019-02-20 11:22:19
@article{29dea83c-a132-455a-9130-f3b0e72d95bc,
  abstract     = {<p>Introduction Anterior cruciate ligament (ACL) injury can result in joint instability, decreased functional performance, reduced physical activity and quality of life and an increased risk for post-traumatic osteoarthritis. Despite the development of new treatment techniques and extensive research, the complex and multifaceted nature of ACL injury and its consequences are yet to be fully understood. The overall aim of the NACOX study is to evaluate the natural corollaries and recovery after an ACL injury. Methods and analysis The NACOX study is a multicentre prospective prognostic cohort study of patients with acute ACL injury. At seven sites in Sweden, we will include patients aged 15-40 years, within 6 weeks after primary ACL injury. Patients will complete questionnaires at multiple occasions over the 3 years following injury or the 3 years following ACL reconstruction (for participants who have surgical treatment). In addition, a subgroup of 130 patients will be followed with clinical examinations, several imaging modalities and biological samples. Data analyses will be specific to each aim. Ethics and dissemination This study has been approved by the regional Ethical committee in Linköping, Sweden (Dnr 2016/44-31 and 2017/221-32). We plan to present the results at national and international conferences and in peer-reviewed scientific journals. Participants will receive a short summary of the results following completion of the study. Trial registration number NCT02931084.</p>},
  articleno    = {e020543},
  author       = {Kvist, Joanna and Gauffin, Håkan and Tigerstrand Grevnerts, Hanna and Ardern, Clare and Hägglund, Martin and Stålman, Anders and Frobell, Richard},
  issn         = {2044-6055},
  keyword      = {knee,magnetic resonance imaging,musculoskeletal disorders,sports medicine},
  language     = {eng},
  month        = {06},
  number       = {6},
  publisher    = {British Medical Journal Publishing Group},
  series       = {BMJ Open},
  title        = {Natural corollaries and recovery after acute ACL injury : The NACOX cohort study protocol},
  url          = {http://dx.doi.org/10.1136/bmjopen-2017-020543},
  volume       = {8},
  year         = {2018},
}