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Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria

Benson, Mikael ; Jodal, Ulf ; Agace, William LU ; Hellström, Mikael ; Mårild, Staffan ; Rosberg, Sten ; Sjöström, Michael ; Wettergren, Björn ; Jönsson, Susanne and Svanborg, Catharina LU (1996) In Journal of Infectious Diseases 174(5). p.1080-1084
Abstract

Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responds were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and... (More)

Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responds were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
174
issue
5
pages
1080 - 1084
publisher
Oxford University Press
external identifiers
  • pmid:8896512
  • scopus:19244363702
ISSN
0022-1899
DOI
10.1093/infdis/174.5.1080
language
English
LU publication?
yes
id
29ee90e9-1bba-4a75-b0a9-e3061c9d6c87
date added to LUP
2019-05-30 13:51:57
date last changed
2020-08-12 08:41:49
@article{29ee90e9-1bba-4a75-b0a9-e3061c9d6c87,
  abstract     = {<p>Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responds were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.</p>},
  author       = {Benson, Mikael and Jodal, Ulf and Agace, William and Hellström, Mikael and Mårild, Staffan and Rosberg, Sten and Sjöström, Michael and Wettergren, Björn and Jönsson, Susanne and Svanborg, Catharina},
  issn         = {0022-1899},
  language     = {eng},
  month        = {01},
  number       = {5},
  pages        = {1080--1084},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria},
  url          = {http://dx.doi.org/10.1093/infdis/174.5.1080},
  doi          = {10.1093/infdis/174.5.1080},
  volume       = {174},
  year         = {1996},
}