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Antithymocyte globulin and cyclosporine A as combination therapy for low-risk non-sideroblastic myelodysplastic syndromes

Broliden, PA; Dahl, IM; Hast, R; Johansson, Bertil LU ; Juvonen, E; Kjeldsen, L; Porwit-MacDonald, A; Sjoo, M; Tangen, JM and Uggla, B, et al. (2006) In Haematologica 91(5). p.667-670
Abstract
The present study evaluated the combination of antithymocyte globulin (ATG) and cyclosporine A (CsA) in patients with low-risk myelodysplastic syndromes. Twenty patients (17 with refractory anemia and 3 with refractory anemia with excess blasts) received treatment with rabbit-ATG plus CsA. The overall response rate was 30% (6/20); three of the six responders had a complete response. The responses lasted 2-58 months, with two patients still being in complete remission at 42 and 58 months. Short-lasting cytogenetic remissions were achieved in two patients. ATG was poorly tolerated in patients over 70 years of age. Four out of 20 patients progressed to acute myeloid leukemia within a year. We conclude that immunosuppressive treatment may be a... (More)
The present study evaluated the combination of antithymocyte globulin (ATG) and cyclosporine A (CsA) in patients with low-risk myelodysplastic syndromes. Twenty patients (17 with refractory anemia and 3 with refractory anemia with excess blasts) received treatment with rabbit-ATG plus CsA. The overall response rate was 30% (6/20); three of the six responders had a complete response. The responses lasted 2-58 months, with two patients still being in complete remission at 42 and 58 months. Short-lasting cytogenetic remissions were achieved in two patients. ATG was poorly tolerated in patients over 70 years of age. Four out of 20 patients progressed to acute myeloid leukemia within a year. We conclude that immunosuppressive treatment may be a therapeutic option for selected patients with myelodysplastic syndrome. (Less)
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Contribution to journal
publication status
published
subject
keywords
cyclosporine A, MDS, ATG, treatment
in
Haematologica
volume
91
issue
5
pages
667 - 670
publisher
Ferrata Storti Foundation
external identifiers
  • wos:000237684000017
  • pmid:16670072
  • scopus:33744492061
ISSN
1592-8721
language
English
LU publication?
yes
id
29fba6d1-d0c3-43f3-9a80-98266d22b724 (old id 408643)
alternative location
http://www.haematologica.org/backissues/details.php?id=38228
date added to LUP
2007-10-01 10:12:24
date last changed
2019-10-13 04:18:58
@article{29fba6d1-d0c3-43f3-9a80-98266d22b724,
  abstract     = {The present study evaluated the combination of antithymocyte globulin (ATG) and cyclosporine A (CsA) in patients with low-risk myelodysplastic syndromes. Twenty patients (17 with refractory anemia and 3 with refractory anemia with excess blasts) received treatment with rabbit-ATG plus CsA. The overall response rate was 30% (6/20); three of the six responders had a complete response. The responses lasted 2-58 months, with two patients still being in complete remission at 42 and 58 months. Short-lasting cytogenetic remissions were achieved in two patients. ATG was poorly tolerated in patients over 70 years of age. Four out of 20 patients progressed to acute myeloid leukemia within a year. We conclude that immunosuppressive treatment may be a therapeutic option for selected patients with myelodysplastic syndrome.},
  author       = {Broliden, PA and Dahl, IM and Hast, R and Johansson, Bertil and Juvonen, E and Kjeldsen, L and Porwit-MacDonald, A and Sjoo, M and Tangen, JM and Uggla, B and Oberg, G and Hellstrom-Lindberg, E},
  issn         = {1592-8721},
  keyword      = {cyclosporine A,MDS,ATG,treatment},
  language     = {eng},
  number       = {5},
  pages        = {667--670},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {Antithymocyte globulin and cyclosporine A as combination therapy for low-risk non-sideroblastic myelodysplastic syndromes},
  volume       = {91},
  year         = {2006},
}