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L-DOPA and graft-induced dyskinesia : different treatment, same story?

Breger, Ludivine S LU and Lane, Emma L LU (2013) In Experimental Biology and Medicine 238(7). p.32-725
Abstract

One of the well-recognized problems of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) therapy in the treatment of Parkinson's disease is the development of L-DOPA induced dyskinesia. These abnormal movements cause significant disability and narrow the therapeutic window of L-DOPA. Cell transplantation is one of the most promising upcoming therapies for the treatment of Parkinson's disease, and may help alleviate or avoid L-DOPA-induced dyskinesia. However, the more recently acknowledged phenomenon of graft-induced dyskinesia is posing a major obstacle to the success of this treatment. This motor side-effect closely resembles abnormal movements induced by chronic L-DOPA treatment, yet they remain after withdrawal of the medication... (More)

One of the well-recognized problems of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) therapy in the treatment of Parkinson's disease is the development of L-DOPA induced dyskinesia. These abnormal movements cause significant disability and narrow the therapeutic window of L-DOPA. Cell transplantation is one of the most promising upcoming therapies for the treatment of Parkinson's disease, and may help alleviate or avoid L-DOPA-induced dyskinesia. However, the more recently acknowledged phenomenon of graft-induced dyskinesia is posing a major obstacle to the success of this treatment. This motor side-effect closely resembles abnormal movements induced by chronic L-DOPA treatment, yet they remain after withdrawal of the medication indicating their origins lie in the transplant. In this review, we compare these two therapy-induced adverse effects, from the way they manifest in patients to the possible mechanisms underlying their development.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Animals, Cell Transplantation, Disease Models, Animal, Dyskinesias, Humans, Levodopa, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Experimental Biology and Medicine
volume
238
issue
7
pages
8 pages
publisher
The Society
external identifiers
  • Scopus:84884189976
ISSN
1535-3702
DOI
10.1177/1535370213488478
language
English
LU publication?
no
id
2a1ad6d9-bc9d-4447-af22-48ade3d84b1d
date added to LUP
2016-10-04 13:03:31
date last changed
2017-01-01 08:35:58
@article{2a1ad6d9-bc9d-4447-af22-48ade3d84b1d,
  abstract     = {<p>One of the well-recognized problems of long-term L-3,4-dihydroxyphenylalanine (L-DOPA) therapy in the treatment of Parkinson's disease is the development of L-DOPA induced dyskinesia. These abnormal movements cause significant disability and narrow the therapeutic window of L-DOPA. Cell transplantation is one of the most promising upcoming therapies for the treatment of Parkinson's disease, and may help alleviate or avoid L-DOPA-induced dyskinesia. However, the more recently acknowledged phenomenon of graft-induced dyskinesia is posing a major obstacle to the success of this treatment. This motor side-effect closely resembles abnormal movements induced by chronic L-DOPA treatment, yet they remain after withdrawal of the medication indicating their origins lie in the transplant. In this review, we compare these two therapy-induced adverse effects, from the way they manifest in patients to the possible mechanisms underlying their development.</p>},
  author       = {Breger, Ludivine S and Lane, Emma L},
  issn         = {1535-3702},
  keyword      = {Animals,Cell Transplantation,Disease Models, Animal,Dyskinesias,Humans,Levodopa,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {7},
  pages        = {32--725},
  publisher    = {The Society},
  series       = {Experimental Biology and Medicine},
  title        = {L-DOPA and graft-induced dyskinesia : different treatment, same story?},
  url          = {http://dx.doi.org/10.1177/1535370213488478},
  volume       = {238},
  year         = {2013},
}