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Brain volumes and developmental outcome in childhood following fetal growth restriction leading to very preterm birth

Morsing, Eva LU ; Malova, Mariya; Kahn, Anna LU ; Lätt, Jimmy LU ; Björkman-Burtscher, Isabella M. LU ; Maršál, Karel LU and Ley, David LU (2018) In Frontiers in Physiology 9(NOV).
Abstract

Background: Children born very preterm (PT) after fetal growth restriction (FGR) exhibit cognitive impairment at early school age. The relationship between neurodevelopmental impairment and attained regional brain volumes is unknown. Methods: We studied 23 preterm children with FGR (PT-FGR), 24 matched preterm children AGA (PT-AGA), and 27 matched term AGA children (T-AGA) by measuring brain volumes with magnetic resonance imaging at early school age. Cognitive and motor functions were assessed by the Wechsler Intelligence Scales for Children and the ABC-Movement score. Results: The mean (SD) full-scale IQ was 80 (17) in the PT-FGR group and 103 (12) in the PT-AGA group (p < 0.001). The PT-FGR group had lower mean total, gray matter,... (More)

Background: Children born very preterm (PT) after fetal growth restriction (FGR) exhibit cognitive impairment at early school age. The relationship between neurodevelopmental impairment and attained regional brain volumes is unknown. Methods: We studied 23 preterm children with FGR (PT-FGR), 24 matched preterm children AGA (PT-AGA), and 27 matched term AGA children (T-AGA) by measuring brain volumes with magnetic resonance imaging at early school age. Cognitive and motor functions were assessed by the Wechsler Intelligence Scales for Children and the ABC-Movement score. Results: The mean (SD) full-scale IQ was 80 (17) in the PT-FGR group and 103 (12) in the PT-AGA group (p < 0.001). The PT-FGR group had lower mean total, gray matter, white matter, thalamic, cerebellar white matter, and hippocampal volumes as compared to the T-AGA group (p = 0.01, 0.04, 0.003, 0.002, 0.001, and 0.009, respectively). Brain volumes did not differ significantly between the PT groups. Reduction of hippocampal volume correlated with degree of growth restriction at birth (r = 0.46, p = 0.05). Neither the full-scale IQ nor the ABC movement score <5th percentile were related to brain volumes. Conclusion: Brain volumes as determined by MRI at early school age were primarily associated with degree of prematurity at birth and less with FGR. Regional brain volumes did not discriminate cognitive and motor function beyond that predicted by gestational age at birth.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain volumes, Fetal growth restriction, Magnetic resonance imaging, Neuro-development, Preterm birth
in
Frontiers in Physiology
volume
9
issue
NOV
publisher
Frontiers
external identifiers
  • scopus:85056990585
ISSN
1664-042X
DOI
10.3389/fphys.2018.01583
language
English
LU publication?
yes
id
2a1fd761-6eca-4db4-8293-1ebcafe9ad14
date added to LUP
2018-12-04 08:36:07
date last changed
2019-03-06 03:00:30
@article{2a1fd761-6eca-4db4-8293-1ebcafe9ad14,
  abstract     = {<p>Background: Children born very preterm (PT) after fetal growth restriction (FGR) exhibit cognitive impairment at early school age. The relationship between neurodevelopmental impairment and attained regional brain volumes is unknown. Methods: We studied 23 preterm children with FGR (PT-FGR), 24 matched preterm children AGA (PT-AGA), and 27 matched term AGA children (T-AGA) by measuring brain volumes with magnetic resonance imaging at early school age. Cognitive and motor functions were assessed by the Wechsler Intelligence Scales for Children and the ABC-Movement score. Results: The mean (SD) full-scale IQ was 80 (17) in the PT-FGR group and 103 (12) in the PT-AGA group (p &lt; 0.001). The PT-FGR group had lower mean total, gray matter, white matter, thalamic, cerebellar white matter, and hippocampal volumes as compared to the T-AGA group (p = 0.01, 0.04, 0.003, 0.002, 0.001, and 0.009, respectively). Brain volumes did not differ significantly between the PT groups. Reduction of hippocampal volume correlated with degree of growth restriction at birth (r = 0.46, p = 0.05). Neither the full-scale IQ nor the ABC movement score &lt;5th percentile were related to brain volumes. Conclusion: Brain volumes as determined by MRI at early school age were primarily associated with degree of prematurity at birth and less with FGR. Regional brain volumes did not discriminate cognitive and motor function beyond that predicted by gestational age at birth.</p>},
  articleno    = {1583},
  author       = {Morsing, Eva and Malova, Mariya and Kahn, Anna and Lätt, Jimmy and Björkman-Burtscher, Isabella M. and Maršál, Karel and Ley, David},
  issn         = {1664-042X},
  keyword      = {Brain volumes,Fetal growth restriction,Magnetic resonance imaging,Neuro-development,Preterm birth},
  language     = {eng},
  month        = {11},
  number       = {NOV},
  publisher    = {Frontiers},
  series       = {Frontiers in Physiology},
  title        = {Brain volumes and developmental outcome in childhood following fetal growth restriction leading to very preterm birth},
  url          = {http://dx.doi.org/10.3389/fphys.2018.01583},
  volume       = {9},
  year         = {2018},
}