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Contribution of obesity associated genetic variants to anthropometric somatotype components

Ibáñez-Zamacona, María Eugenia ; Poveda, Alaitz LU orcid and Rebato, Esther (2019) In Anthropologischer Anzeiger 76(2). p.101-111
Abstract

The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 years old. A literature search was conducted in PubMed to select genetic variants associated with obesity in European derived populations. After the quality control of the chosen variants, 21 SNPs were finally used to conduct association analyses. Logistic and linear regressions implemented in PLINK (v1.07) were used to assess the association... (More)

The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 years old. A literature search was conducted in PubMed to select genetic variants associated with obesity in European derived populations. After the quality control of the chosen variants, 21 SNPs were finally used to conduct association analyses. Logistic and linear regressions implemented in PLINK (v1.07) were used to assess the association between SNPs and the somatotype. Two genetic variants (rs925946 in BDNF and rs10146997 in NRXN3) showed a significant association with endomorphy (p < 0.01) while rs10146997 (in NRXN3) and rs9939609 (in FTO) were associated with mesomorphy (p < 0.01). rs925946 (in BDNF), rs10146997 (in NRXN3), rs9939609 (in FTO) and rs4776970 (in MAP2K5) were associated with ectomorphy (p < 0.05). In conclusion, four genetic variants (in or near BDNF, NRXN3, MAP2K5 and FTO) contribute to body shape and composition in the analysed sample.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anthropometric somatotype, BMI, Genetic variants, Obesity, SNPs
in
Anthropologischer Anzeiger
volume
76
issue
2
pages
11 pages
publisher
E. Schweizerbart Science Publishers
external identifiers
  • pmid:30907917
  • scopus:85067835023
ISSN
0003-5548
DOI
10.1127/anthranz/2019/0945
language
English
LU publication?
yes
id
2a38ad99-40b4-4419-8c5b-30489241325e
date added to LUP
2019-07-08 10:55:17
date last changed
2024-05-29 23:13:26
@article{2a38ad99-40b4-4419-8c5b-30489241325e,
  abstract     = {{<p>The somatotype is a useful method in the analysis of body morphology but no study has identified genetic variants associated with its components. The aim of this study is o replicate the association of 21 SNPs with obesity and to explore their association with the somatotype components, in a sample from the Basque Country (Spain). A case-control study was performed in 472 adults from 18 to 79 years old. A literature search was conducted in PubMed to select genetic variants associated with obesity in European derived populations. After the quality control of the chosen variants, 21 SNPs were finally used to conduct association analyses. Logistic and linear regressions implemented in PLINK (v1.07) were used to assess the association between SNPs and the somatotype. Two genetic variants (rs925946 in BDNF and rs10146997 in NRXN3) showed a significant association with endomorphy (p &lt; 0.01) while rs10146997 (in NRXN3) and rs9939609 (in FTO) were associated with mesomorphy (p &lt; 0.01). rs925946 (in BDNF), rs10146997 (in NRXN3), rs9939609 (in FTO) and rs4776970 (in MAP2K5) were associated with ectomorphy (p &lt; 0.05). In conclusion, four genetic variants (in or near BDNF, NRXN3, MAP2K5 and FTO) contribute to body shape and composition in the analysed sample.</p>}},
  author       = {{Ibáñez-Zamacona, María Eugenia and Poveda, Alaitz and Rebato, Esther}},
  issn         = {{0003-5548}},
  keywords     = {{Anthropometric somatotype; BMI; Genetic variants; Obesity; SNPs}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{101--111}},
  publisher    = {{E. Schweizerbart Science Publishers}},
  series       = {{Anthropologischer Anzeiger}},
  title        = {{Contribution of obesity associated genetic variants to anthropometric somatotype components}},
  url          = {{http://dx.doi.org/10.1127/anthranz/2019/0945}},
  doi          = {{10.1127/anthranz/2019/0945}},
  volume       = {{76}},
  year         = {{2019}},
}