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Proteomic analysis of cell fate decision

Hansson, Jenny LU and Krijgsveld, Jeroen (2013) In Current Opinion in Genetics & Development 23(5). p.7-540
Abstract

The field of proteomics is progressing at a rapid pace, developing from primarily a specialist technology to a valuable tool in biological research. Importantly, the establishment of mass spectrometry as a quantitative method, miniaturisation of liquid chromatography techniques, and improved sensitivity of mass-spectrometric instrumentation now enable near-complete monitoring of cellular proteome dynamics. An increasing number of studies are therefore now applying quantitative proteomics to study proteins and posttranslational modifications in stem cells, to reveal molecular mechanisms and pathways underlying pluripotency, differentiation and reprogramming.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Cell Differentiation, Cell Lineage, Cellular Reprogramming, Chromatography, Liquid, Humans, Induced Pluripotent Stem Cells, Mass Spectrometry, Protein Processing, Post-Translational, Proteome, Proteomics, Signal Transduction
in
Current Opinion in Genetics & Development
volume
23
issue
5
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:84883826084
ISSN
1879-0380
DOI
10.1016/j.gde.2013.06.004
language
English
LU publication?
no
id
2a3af651-0961-475c-b0a0-30be595762df
date added to LUP
2016-04-19 10:19:35
date last changed
2017-01-01 08:23:18
@article{2a3af651-0961-475c-b0a0-30be595762df,
  abstract     = {<p>The field of proteomics is progressing at a rapid pace, developing from primarily a specialist technology to a valuable tool in biological research. Importantly, the establishment of mass spectrometry as a quantitative method, miniaturisation of liquid chromatography techniques, and improved sensitivity of mass-spectrometric instrumentation now enable near-complete monitoring of cellular proteome dynamics. An increasing number of studies are therefore now applying quantitative proteomics to study proteins and posttranslational modifications in stem cells, to reveal molecular mechanisms and pathways underlying pluripotency, differentiation and reprogramming.</p>},
  author       = {Hansson, Jenny and Krijgsveld, Jeroen},
  issn         = {1879-0380},
  keyword      = {Cell Differentiation,Cell Lineage,Cellular Reprogramming,Chromatography, Liquid,Humans,Induced Pluripotent Stem Cells,Mass Spectrometry,Protein Processing, Post-Translational,Proteome,Proteomics,Signal Transduction},
  language     = {eng},
  number       = {5},
  pages        = {7--540},
  publisher    = {Elsevier},
  series       = {Current Opinion in Genetics & Development},
  title        = {Proteomic analysis of cell fate decision},
  url          = {http://dx.doi.org/10.1016/j.gde.2013.06.004},
  volume       = {23},
  year         = {2013},
}