Prevention of diabetes in nonobese diabetic mice mediated by CD1d-restricted nonclassical NKT cells
(2004) In Journal of Immunology 173(5). p.3112-3118- Abstract
- A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type I diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4 by these cells and a role for classical NKT cells, using the Valpha14-Jalpha18 rearrangement. We now show that overexpression in NOD mice of CD1d-restricted TCR Valpha3.2(+)Vbeta9(+) NKT cells producing high levels of IFN-gamma but low amounts of IL-4 leads to prevention of type 1 diabetes, demonstrating a role for nonclassical CD1d-restricted NKT... (More)
- A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type I diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4 by these cells and a role for classical NKT cells, using the Valpha14-Jalpha18 rearrangement. We now show that overexpression in NOD mice of CD1d-restricted TCR Valpha3.2(+)Vbeta9(+) NKT cells producing high levels of IFN-gamma but low amounts of IL-4 leads to prevention of type 1 diabetes, demonstrating a role for nonclassical CD1d-restricted NKT cells in the regulation of autoimmune diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/268498
- author
- Duarte, N ; Stenström, Martin LU ; Campino, S ; Bergman, ML ; Lundholm, M ; Holmberg, D and Cardell, Susanna LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Immunology
- volume
- 173
- issue
- 5
- pages
- 3112 - 3118
- publisher
- American Association of Immunologists
- external identifiers
-
- wos:000223529800033
- pmid:15322171
- scopus:4344605002
- ISSN
- 1550-6606
- language
- English
- LU publication?
- yes
- id
- 2a662924-c5f3-49cf-82ae-b8ea40cb7d3d (old id 268498)
- alternative location
- http://www.jimmunol.org/cgi/content/abstract/173/5/3112
- date added to LUP
- 2016-04-01 16:17:00
- date last changed
- 2022-02-20 05:01:31
@article{2a662924-c5f3-49cf-82ae-b8ea40cb7d3d,
abstract = {{A role for regulatory lymphocytes has been demonstrated in the pathogenesis of type I diabetes in the NOD mouse but the nature of these cells is debated. CD1d-restricted NKT lymphocytes have been implicated in this process. Previous reports of reduced diabetes incidence in NOD mice in which the numbers of NKT cells are artificially increased have been attributed to the enhanced production of IL-4 by these cells and a role for classical NKT cells, using the Valpha14-Jalpha18 rearrangement. We now show that overexpression in NOD mice of CD1d-restricted TCR Valpha3.2(+)Vbeta9(+) NKT cells producing high levels of IFN-gamma but low amounts of IL-4 leads to prevention of type 1 diabetes, demonstrating a role for nonclassical CD1d-restricted NKT cells in the regulation of autoimmune diabetes.}},
author = {{Duarte, N and Stenström, Martin and Campino, S and Bergman, ML and Lundholm, M and Holmberg, D and Cardell, Susanna}},
issn = {{1550-6606}},
language = {{eng}},
number = {{5}},
pages = {{3112--3118}},
publisher = {{American Association of Immunologists}},
series = {{Journal of Immunology}},
title = {{Prevention of diabetes in nonobese diabetic mice mediated by CD1d-restricted nonclassical NKT cells}},
url = {{http://www.jimmunol.org/cgi/content/abstract/173/5/3112}},
volume = {{173}},
year = {{2004}},
}