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Research Priorities in Pediatric Asthma : Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank

Mathioudakis, Alexander G. ; Custovic, Adnan ; Deschildre, Antoine ; Ducharme, Francine M. ; Kalayci, Omer ; Murray, Clare ; Garcia, Antonio Nieto ; Phipatanakul, Wanda ; Price, David and Sheikh, Aziz , et al. (2020) In Journal of Allergy and Clinical Immunology: In Practice 8(6). p.9-1960
Abstract

Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared.... (More)

Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared. Results: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations. Conclusions: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Assessment, Asthma, Childhood asthma, Clinical research, Diagnosis, Management, Pediatric asthma, Research priorities
in
Journal of Allergy and Clinical Immunology: In Practice
volume
8
issue
6
pages
9 - 1960
publisher
Elsevier
external identifiers
  • scopus:85081199992
  • pmid:32146166
ISSN
2213-2198
DOI
10.1016/j.jaip.2020.01.059
language
English
LU publication?
yes
id
2acbaebe-3dd1-4d35-9230-faed992e8170
date added to LUP
2020-03-27 11:02:20
date last changed
2021-04-13 03:43:45
@article{2acbaebe-3dd1-4d35-9230-faed992e8170,
  abstract     = {<p>Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma who were members of the Pediatric Asthma in Real Life Think Tank. Prioritization of topics was then achieved through a second, extensive survey with global reach, of multiple stakeholders (leading experts, researchers, clinicians, patients, policy makers, and the pharmaceutical industry). Differences across responder groups were compared. Results: A total of 57 unmet clinical need topics identified by international experts were prioritized by 412 participants from 5 continents and 60 countries. Prevention of disease progression and prediction of future risk, including persistence into adulthood, emerged as the most urgent research questions. Stratified care, based on biomarkers, clinical phenotypes, the children's age, and demographics were also highly rated. The identification of minimum diagnostic criteria in different age groups, cultural perceptions of asthma, and best treatment by age group were priorities for responders from low-middle-income countries. There was good agreement across different stakeholder groups in all domains with some notable exceptions that highlight the importance of involving the whole range of stakeholders in formulation of recommendations. Conclusions: Different stakeholders agree in the majority of research and strategic (eg, prevention, personalized approach) priorities for pediatric asthma. Stakeholder diversity is crucial for highlighting divergent issues that future guidelines should consider.</p>},
  author       = {Mathioudakis, Alexander G. and Custovic, Adnan and Deschildre, Antoine and Ducharme, Francine M. and Kalayci, Omer and Murray, Clare and Garcia, Antonio Nieto and Phipatanakul, Wanda and Price, David and Sheikh, Aziz and Agache, Ioana and Bacharier, Leonard and Bonini, Matteo and Castro-Rodriguez, Jose A. and De Carlo, Giuseppe and Craig, Timothy and Diamant, Zuzana and Feleszko, Wojciech and Ierodiakonou, Despo and Gern, James E. and Grigg, Jonathan and Hedlin, Gunilla and Hossny, Elham M. and Jartti, Tuomas and Kaplan, Alan and Lemanske, Robert F. and Le Souef, Peter and Makela, Mika J. and Matricardi, Paolo M. and Miligkos, Michael and Morais-Almeida, Mário and Pite, Helena and Pitrez, Paulo M.C. and Pohunek, Petr and Roberts, Graham and Sanchez-Garcia, Sylvia and Tsiligianni, Ioanna and Turner, Steve and Winders, Tonya A. and Wong, Gary and Xepapadaki, Paraskevi and Zar, Heather J. and Papadopoulos, Nikolaos G.},
  issn         = {2213-2198},
  language     = {eng},
  number       = {6},
  pages        = {9--1960},
  publisher    = {Elsevier},
  series       = {Journal of Allergy and Clinical Immunology: In Practice},
  title        = {Research Priorities in Pediatric Asthma : Results of a Global Survey of Multiple Stakeholder Groups by the Pediatric Asthma in Real Life (PeARL) Think Tank},
  url          = {http://dx.doi.org/10.1016/j.jaip.2020.01.059},
  doi          = {10.1016/j.jaip.2020.01.059},
  volume       = {8},
  year         = {2020},
}