Myotonia in colchicine myoneuropathy
Rutkove, Seward B. ; De Girolami, Umberto ; Preston, David C. ; Freeman, Roy ; Nardin, Rachel A. ; Gouras, Gunnar K. LU
; Johns, Donald R.
and Raynor, Elizabeth M.
(1996)
In Muscle and Nerve
19(7).
p.870-875
- Abstract
Colchicine may induce a myoneuropathy in patients with renal insufficiency. To date, myotonia has not been described in this disorder. We recently studied 4 patients treated with routine doses of colchicine who, in the setting of renal insufficiency, developed a severe myoneuropathy characterized by prominent myotonic discharges on electromyography. In addition, 1 of the 4 patients had profound clinical myotonia. In the 3 patients in whom biopsies were performed, marked myopathic change with intracytoplasmic vacuolization was identified. All 4 patients improved rapidly with discontinuation of the medication. The patient in whom electrophysiologic studies were repeated had a complete resolution of the myotonic discharges. Colchicine... (More)
Colchicine may induce a myoneuropathy in patients with renal insufficiency. To date, myotonia has not been described in this disorder. We recently studied 4 patients treated with routine doses of colchicine who, in the setting of renal insufficiency, developed a severe myoneuropathy characterized by prominent myotonic discharges on electromyography. In addition, 1 of the 4 patients had profound clinical myotonia. In the 3 patients in whom biopsies were performed, marked myopathic change with intracytoplasmic vacuolization was identified. All 4 patients improved rapidly with discontinuation of the medication. The patient in whom electrophysiologic studies were repeated had a complete resolution of the myotonic discharges. Colchicine myoneuropathy can present with prominent clinical and electrophysiologic myotonia that resolves completely with discontinuation of the medication.
(Less)
- author
- Rutkove, Seward B.
; De Girolami, Umberto
; Preston, David C.
; Freeman, Roy
; Nardin, Rachel A.
; Gouras, Gunnar K.
LU
; Johns, Donald R.
and Raynor, Elizabeth M.
- publishing date
- 1996-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- colchicine, myopathy, myotonia, renal insufficiency
- in
- Muscle and Nerve
- volume
- 19
- issue
- 7
- pages
- 870 - 875
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8965841
- scopus:0030014793
- ISSN
- 0148-639X
- DOI
- 10.1002/(SICI)1097-4598(199607)19:7<870::AID-MUS9>3.0.CO;2-6
- language
- English
- LU publication?
- no
- id
- 2aface11-b828-4061-a958-c14393a934cd
- date added to LUP
- 2020-02-20 14:44:18
- date last changed
- 2024-01-02 06:10:50
@article{2aface11-b828-4061-a958-c14393a934cd,
abstract = {{<p>Colchicine may induce a myoneuropathy in patients with renal insufficiency. To date, myotonia has not been described in this disorder. We recently studied 4 patients treated with routine doses of colchicine who, in the setting of renal insufficiency, developed a severe myoneuropathy characterized by prominent myotonic discharges on electromyography. In addition, 1 of the 4 patients had profound clinical myotonia. In the 3 patients in whom biopsies were performed, marked myopathic change with intracytoplasmic vacuolization was identified. All 4 patients improved rapidly with discontinuation of the medication. The patient in whom electrophysiologic studies were repeated had a complete resolution of the myotonic discharges. Colchicine myoneuropathy can present with prominent clinical and electrophysiologic myotonia that resolves completely with discontinuation of the medication.</p>}},
author = {{Rutkove, Seward B. and De Girolami, Umberto and Preston, David C. and Freeman, Roy and Nardin, Rachel A. and Gouras, Gunnar K. and Johns, Donald R. and Raynor, Elizabeth M.}},
issn = {{0148-639X}},
keywords = {{colchicine; myopathy; myotonia; renal insufficiency}},
language = {{eng}},
month = {{07}},
number = {{7}},
pages = {{870--875}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Muscle and Nerve}},
title = {{Myotonia in colchicine myoneuropathy}},
url = {{http://dx.doi.org/10.1002/(SICI)1097-4598(199607)19:7<870::AID-MUS9>3.0.CO;2-6}},
doi = {{10.1002/(SICI)1097-4598(199607)19:7<870::AID-MUS9>3.0.CO;2-6}},
volume = {{19}},
year = {{1996}},
}