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Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer

Shigeyama, Munehisa ; Yoshihara, Masato ; Kitami, Kazuhisa ; Mogi, Kazumasa ; Uno, Kaname LU orcid ; Iyoshi, Shohei ; Tano, Sho ; Yoshikawa, Nobuhisa and Kajiyama, Hiroaki (2021) In European Journal of Obstetrics and Gynecology and Reproductive Biology 267. p.221-225
Abstract

Objective: The aim of this study was to investigate long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery (FSS) to verify the feasibility of the limited surgery for epithelial ovarian cancer (OvCa). Study design: We performed a regional multicenter retrospective study from January 1986 and March 2020, using clinical data corrected under the central pathological review system. Patients with recurrent tumor after surgery for stage I epithelial OvCa, aged equal or younger than 45 years were included for this study. We evaluated effect of FSS regarding long-term post-recurrence survival with statistical adjustment of propensity score-based method. Results: With the Kaplan–Meier method, original and... (More)

Objective: The aim of this study was to investigate long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery (FSS) to verify the feasibility of the limited surgery for epithelial ovarian cancer (OvCa). Study design: We performed a regional multicenter retrospective study from January 1986 and March 2020, using clinical data corrected under the central pathological review system. Patients with recurrent tumor after surgery for stage I epithelial OvCa, aged equal or younger than 45 years were included for this study. We evaluated effect of FSS regarding long-term post-recurrence survival with statistical adjustment of propensity score-based method. Results: With the Kaplan–Meier method, original and adjusted survival curves were estimated for recurrence-after survival of patients with (n = 14) and without FSS (n = 26). Median time to disease-specific death was 18.6 months. In both original and adjusted cohorts, there were no significant difference between the two groups (log rank test; P > 0.05). Hazard ratio of disease-specific death was 1.264 (95% confidence interval, 0.563–2.836; P = 0.570) in original and 1.354 (95% confidence interval, 0.702–2.611; P = 0.366) in adjusted population. This result indicated that patients with FSS was not associated with poorer prognosis for recurrence-after survival than those without. When comparing patients not receiving FSS, patients receiving FSS with recurrence at spared ovary followed not significantly different survival outcome as well as those with extra-ovarian recurrence. Conclusion: There was no significant difference of long-term post-recurrence survival outcomes between patients of epithelial OvCa with and without FSS in young women of reproductive age.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epithelial ovarian cancer, Fertility preservation, Longterm effects, Recurrence
in
European Journal of Obstetrics and Gynecology and Reproductive Biology
volume
267
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:85119627681
  • pmid:34826670
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2021.11.015
language
English
LU publication?
yes
id
2b073c7e-7753-44be-9682-e11724f8e2f2
date added to LUP
2021-12-08 13:45:56
date last changed
2024-06-15 22:16:38
@article{2b073c7e-7753-44be-9682-e11724f8e2f2,
  abstract     = {{<p>Objective: The aim of this study was to investigate long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery (FSS) to verify the feasibility of the limited surgery for epithelial ovarian cancer (OvCa). Study design: We performed a regional multicenter retrospective study from January 1986 and March 2020, using clinical data corrected under the central pathological review system. Patients with recurrent tumor after surgery for stage I epithelial OvCa, aged equal or younger than 45 years were included for this study. We evaluated effect of FSS regarding long-term post-recurrence survival with statistical adjustment of propensity score-based method. Results: With the Kaplan–Meier method, original and adjusted survival curves were estimated for recurrence-after survival of patients with (n = 14) and without FSS (n = 26). Median time to disease-specific death was 18.6 months. In both original and adjusted cohorts, there were no significant difference between the two groups (log rank test; P &gt; 0.05). Hazard ratio of disease-specific death was 1.264 (95% confidence interval, 0.563–2.836; P = 0.570) in original and 1.354 (95% confidence interval, 0.702–2.611; P = 0.366) in adjusted population. This result indicated that patients with FSS was not associated with poorer prognosis for recurrence-after survival than those without. When comparing patients not receiving FSS, patients receiving FSS with recurrence at spared ovary followed not significantly different survival outcome as well as those with extra-ovarian recurrence. Conclusion: There was no significant difference of long-term post-recurrence survival outcomes between patients of epithelial OvCa with and without FSS in young women of reproductive age.</p>}},
  author       = {{Shigeyama, Munehisa and Yoshihara, Masato and Kitami, Kazuhisa and Mogi, Kazumasa and Uno, Kaname and Iyoshi, Shohei and Tano, Sho and Yoshikawa, Nobuhisa and Kajiyama, Hiroaki}},
  issn         = {{0301-2115}},
  keywords     = {{Epithelial ovarian cancer; Fertility preservation; Longterm effects; Recurrence}},
  language     = {{eng}},
  pages        = {{221--225}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Obstetrics and Gynecology and Reproductive Biology}},
  title        = {{Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer}},
  url          = {{http://dx.doi.org/10.1016/j.ejogrb.2021.11.015}},
  doi          = {{10.1016/j.ejogrb.2021.11.015}},
  volume       = {{267}},
  year         = {{2021}},
}