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Brain metabolic alterations in mice subjected to postnatal traumatic stress and in their offspring

Gapp, Katharina; Corcoba, Alberto; van Steenwyk, Gretchen; Mansuy, Isabelle M. and Duarte, João Mn LU (2017) In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37(7). p.2423-2432
Abstract

Adverse environmental and social conditions early in life have a strong impact on health. They are major risk factors for mental diseases in adulthood and, in some cases, their effects can be transmitted across generations. The consequences of detrimental stress conditions on brain metabolism across generations are not well known. Using high-field (14.1 T) magnetic resonance spectroscopy, we investigated the neurochemical profile of adult male mice exposed to traumatic stress in early postnatal life and of their offspring, and of undisturbed control mice. We found that, relative to controls, early life stress-exposed mice have metabolic alterations consistent with neuronal dysfunction, including reduced concentration of... (More)

Adverse environmental and social conditions early in life have a strong impact on health. They are major risk factors for mental diseases in adulthood and, in some cases, their effects can be transmitted across generations. The consequences of detrimental stress conditions on brain metabolism across generations are not well known. Using high-field (14.1 T) magnetic resonance spectroscopy, we investigated the neurochemical profile of adult male mice exposed to traumatic stress in early postnatal life and of their offspring, and of undisturbed control mice. We found that, relative to controls, early life stress-exposed mice have metabolic alterations consistent with neuronal dysfunction, including reduced concentration of N-acetylaspartate, glutamate and γ-aminobutyrate, in the prefrontal cortex in basal conditions. Their offspring have normal neurochemical profiles in basal conditions. Remarkably, when challenged by an acute cold swim stress, the offspring has attenuated metabolic responses in the prefrontal cortex, hippocampus and striatum. In particular, the expected stress-induced reduction in the concentration of N-acetylaspartate, a putative marker of neuronal health, was prevented in the cortex and hippocampus. These findings suggest that paternal trauma can confer beneficial brain metabolism adaptations to acute stress in the offspring.

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author
publishing date
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Contribution to journal
publication status
published
keywords
Animals, Animals, Newborn, Brain, Brain Chemistry, Cerebral Cortex, Corpus Striatum, Female, Hippocampus, Magnetic Resonance Spectroscopy, Male, Maternal Deprivation, Mice, Inbred C57BL, Pregnancy, Prenatal Exposure Delayed Effects, Restraint, Physical, Stress, Psychological, Swimming
in
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
volume
37
issue
7
pages
10 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85021066125
ISSN
1559-7016
DOI
10.1177/0271678X16667525
language
English
LU publication?
no
id
2b0ec399-6b58-407a-89e7-0cace9e2a1a6
date added to LUP
2017-10-19 15:07:08
date last changed
2018-01-07 12:23:03
@article{2b0ec399-6b58-407a-89e7-0cace9e2a1a6,
  abstract     = {<p>Adverse environmental and social conditions early in life have a strong impact on health. They are major risk factors for mental diseases in adulthood and, in some cases, their effects can be transmitted across generations. The consequences of detrimental stress conditions on brain metabolism across generations are not well known. Using high-field (14.1 T) magnetic resonance spectroscopy, we investigated the neurochemical profile of adult male mice exposed to traumatic stress in early postnatal life and of their offspring, and of undisturbed control mice. We found that, relative to controls, early life stress-exposed mice have metabolic alterations consistent with neuronal dysfunction, including reduced concentration of N-acetylaspartate, glutamate and γ-aminobutyrate, in the prefrontal cortex in basal conditions. Their offspring have normal neurochemical profiles in basal conditions. Remarkably, when challenged by an acute cold swim stress, the offspring has attenuated metabolic responses in the prefrontal cortex, hippocampus and striatum. In particular, the expected stress-induced reduction in the concentration of N-acetylaspartate, a putative marker of neuronal health, was prevented in the cortex and hippocampus. These findings suggest that paternal trauma can confer beneficial brain metabolism adaptations to acute stress in the offspring.</p>},
  author       = {Gapp, Katharina and Corcoba, Alberto and van Steenwyk, Gretchen and Mansuy, Isabelle M.  and Duarte, João Mn},
  issn         = {1559-7016},
  keyword      = {Animals,Animals, Newborn,Brain,Brain Chemistry,Cerebral Cortex,Corpus Striatum,Female,Hippocampus,Magnetic Resonance Spectroscopy,Male,Maternal Deprivation,Mice, Inbred C57BL,Pregnancy,Prenatal Exposure Delayed Effects,Restraint, Physical,Stress, Psychological,Swimming},
  language     = {eng},
  number       = {7},
  pages        = {2423--2432},
  publisher    = {Nature Publishing Group},
  series       = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  title        = {Brain metabolic alterations in mice subjected to postnatal traumatic stress and in their offspring},
  url          = {http://dx.doi.org/10.1177/0271678X16667525},
  volume       = {37},
  year         = {2017},
}