40 Hz invisible spectral flicker and its potential use in Alzheimer's light therapy treatment
Carstensen, Marcus S. ; Lindén, Johannes LU
; Nguyen, N. Mai
; Hansen, Henrik E.
; Feijóo Carrillo, Gustavo M.
; Hansen, Luna S.
; Corell, Dennis D.
; Broeng, Jes
; Kriegsfeld, Lance J.
and Petersen, Paul Michael
(2020)
Mechanisms of Photobiomodulation Therapy XV 2020
In Progress in Biomedical Optics and Imaging - Proceedings of SPIE
11221.
p.1-12
- Abstract
Alzheimer's disease (AD) not only takes an emotional toll on the individual with the disease, their families, relatives, and caretakers, it also has immense socioeconomic consequences on the health care system and society. Moreover, the socioeconomic consequences are expected to increase significantly, thus reducing the social and economic cost of AD is of high importance. Recently, exposure to 40 Hz stroboscopic light therapy, for one hour a day, resulted in slowing the progression of AD in mice and has a considerable potential for treatment in humans. However, exposure to such stroboscopic light carries its own consequences being that it is difficult to implement in a patient's daily routine, irksome to use, and can cause visual... (More)
Alzheimer's disease (AD) not only takes an emotional toll on the individual with the disease, their families, relatives, and caretakers, it also has immense socioeconomic consequences on the health care system and society. Moreover, the socioeconomic consequences are expected to increase significantly, thus reducing the social and economic cost of AD is of high importance. Recently, exposure to 40 Hz stroboscopic light therapy, for one hour a day, resulted in slowing the progression of AD in mice and has a considerable potential for treatment in humans. However, exposure to such stroboscopic light carries its own consequences being that it is difficult to implement in a patient's daily routine, irksome to use, and can cause visual discomfort which may result in a lack of patient adherence. Here, we demonstrate a novel technology based on controlling multiple single-color LEDs to produce white light where its spectral composition alternates at a given modulation frequency without visible flicker. We coin this technique as Invisible Spectral Flicker (ISF). We present 40 Hz invisible spectral flicker light as a potential alternative in reducing discomfort compared to 40 Hz stroboscopic light, whilst still entraining oscillations in various areas of the brain. Furthermore, we demonstrate a distinct way to generate a 40 Hz metameric light source with the presented color mixing scheme, and validate that the CIE 1931 (x, y) coordinates match for two different spectral power distributions. Finally, we illustrate the light characteristics of seven 40 Hz color fusion light sources and two 40 Hz stroboscopic light sources. The technology presented here will lead to new, and hopefully improved, designs of light therapy systems for the treatment of Alzheimer's and dementia.
(Less)
- author
- Carstensen, Marcus S.
; Lindén, Johannes
LU
; Nguyen, N. Mai
; Hansen, Henrik E.
; Feijóo Carrillo, Gustavo M.
; Hansen, Luna S.
; Corell, Dennis D.
; Broeng, Jes
; Kriegsfeld, Lance J.
and Petersen, Paul Michael
- publishing date
- 2020-03-11
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- 40 Hz, Alzheimer's Disease, Chromaticity, Color, Flicker, Invisible Flicker, Light Therapy, Metamerism
- host publication
- Mechanisms of Photobiomodulation Therapy XV
- series title
- Progress in Biomedical Optics and Imaging - Proceedings of SPIE
- editor
- Hamblin, Michael R. ; Carroll, James D. and Arany, Praveen
- volume
- 11221
- article number
- 112210L
- pages
- 12 pages
- publisher
- SPIE
- conference name
- Mechanisms of Photobiomodulation Therapy XV 2020
- conference location
- San Francisco, United States
- conference dates
- 2020-02-01
- external identifiers
-
- scopus:85082767614
- ISSN
- 1605-7422
- ISBN
- 9781510632059
- DOI
- 10.1117/12.2544338
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
- id
- 2b62610a-876e-4052-b1c4-cd9a333b3a91
- date added to LUP
- 2022-06-02 17:28:10
- date last changed
- 2022-06-24 00:31:26
@inproceedings{2b62610a-876e-4052-b1c4-cd9a333b3a91,
abstract = {{<p>Alzheimer's disease (AD) not only takes an emotional toll on the individual with the disease, their families, relatives, and caretakers, it also has immense socioeconomic consequences on the health care system and society. Moreover, the socioeconomic consequences are expected to increase significantly, thus reducing the social and economic cost of AD is of high importance. Recently, exposure to 40 Hz stroboscopic light therapy, for one hour a day, resulted in slowing the progression of AD in mice and has a considerable potential for treatment in humans. However, exposure to such stroboscopic light carries its own consequences being that it is difficult to implement in a patient's daily routine, irksome to use, and can cause visual discomfort which may result in a lack of patient adherence. Here, we demonstrate a novel technology based on controlling multiple single-color LEDs to produce white light where its spectral composition alternates at a given modulation frequency without visible flicker. We coin this technique as Invisible Spectral Flicker (ISF). We present 40 Hz invisible spectral flicker light as a potential alternative in reducing discomfort compared to 40 Hz stroboscopic light, whilst still entraining oscillations in various areas of the brain. Furthermore, we demonstrate a distinct way to generate a 40 Hz metameric light source with the presented color mixing scheme, and validate that the CIE 1931 (x, y) coordinates match for two different spectral power distributions. Finally, we illustrate the light characteristics of seven 40 Hz color fusion light sources and two 40 Hz stroboscopic light sources. The technology presented here will lead to new, and hopefully improved, designs of light therapy systems for the treatment of Alzheimer's and dementia.</p>}},
author = {{Carstensen, Marcus S. and Lindén, Johannes and Nguyen, N. Mai and Hansen, Henrik E. and Feijóo Carrillo, Gustavo M. and Hansen, Luna S. and Corell, Dennis D. and Broeng, Jes and Kriegsfeld, Lance J. and Petersen, Paul Michael}},
booktitle = {{Mechanisms of Photobiomodulation Therapy XV}},
editor = {{Hamblin, Michael R. and Carroll, James D. and Arany, Praveen}},
isbn = {{9781510632059}},
issn = {{1605-7422}},
keywords = {{40 Hz; Alzheimer's Disease; Chromaticity; Color; Flicker; Invisible Flicker; Light Therapy; Metamerism}},
language = {{eng}},
month = {{03}},
pages = {{1--12}},
publisher = {{SPIE}},
series = {{Progress in Biomedical Optics and Imaging - Proceedings of SPIE}},
title = {{40 Hz invisible spectral flicker and its potential use in Alzheimer's light therapy treatment}},
url = {{http://dx.doi.org/10.1117/12.2544338}},
doi = {{10.1117/12.2544338}},
volume = {{11221}},
year = {{2020}},
}