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Patient-reported outcomes and preferences for colon capsule endoscopy and colonoscopy : A systematic review with meta-analysis

Deding, Ulrik ; Valdivia, Pablo Cortegoso ; Koulaouzidis, Anastasios LU ; Baatrup, Gunnar ; Toth, Ervin LU ; Spada, Cristiano ; Fernández-Urién, Ignacio ; Pennazio, Marco and Bjørsum-Meyer, Thomas (2021) In Diagnostics 11(9).
Abstract

Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature search was conducted in Web of Science, PubMed and Embase. Search results were thoroughly screened for in-and exclusion criteria. Included studies underwent assessment of transparency and completeness, after which, data for meta-analysis were extracted. Pooled estimates of patient preference were calculated and heterogeneity was examined including... (More)

Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature search was conducted in Web of Science, PubMed and Embase. Search results were thoroughly screened for in-and exclusion criteria. Included studies underwent assessment of transparency and completeness, after which, data for meta-analysis were extracted. Pooled estimates of patient preference were calculated and heterogeneity was examined including univariate meta-regressions. Patient-reported tolerability and adverse events were reviewed. Out of fourteen included studies, twelve had investigated patient-reported outcomes in patients who had undergone both investigations, whereas in two the patients were randomized between investigations. Pooled patient preferences were estimated to be 52% (CI 95%: 41–63%) for colon capsule endoscopy and 45% (CI 95%: 33–57%) for conventional colonoscopy: not indicating a significant difference. Procedural adverse events were rarely reported by patients for either investigation. The tolerability was high for both colon capsule endoscopy and conventional colonoscopy. Patient preferences for conventional colonoscopy and colon capsule endoscopy were not significantly different. Procedural adverse events were rare and the tolerability for colon capsule endoscopy was consistently reported higher or equal to that of conventional colonoscopy.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colon capsule endoscopy, Colonoscopy, Endoscopy, Patient-reported outcomes
in
Diagnostics
volume
11
issue
9
article number
1730
publisher
MDPI AG
external identifiers
  • scopus:85116594175
  • pmid:34574071
ISSN
2075-4418
DOI
10.3390/diagnostics11091730
language
English
LU publication?
yes
id
2b6386ec-1118-4a5e-bc20-1444ff7f3f87
date added to LUP
2022-03-22 17:04:39
date last changed
2024-06-21 02:45:34
@article{2b6386ec-1118-4a5e-bc20-1444ff7f3f87,
  abstract     = {{<p>Colon capsule endoscopy as an alternative to colonoscopy for the diagnosis of colonic disease may serve as a less invasive and more tolerable investigation for patients. Our aim was to examine patient-reported outcomes for colon capsule endoscopy compared to conventional optical colonoscopy including preference of investigation modality, tolerability and adverse events. A systematic literature search was conducted in Web of Science, PubMed and Embase. Search results were thoroughly screened for in-and exclusion criteria. Included studies underwent assessment of transparency and completeness, after which, data for meta-analysis were extracted. Pooled estimates of patient preference were calculated and heterogeneity was examined including univariate meta-regressions. Patient-reported tolerability and adverse events were reviewed. Out of fourteen included studies, twelve had investigated patient-reported outcomes in patients who had undergone both investigations, whereas in two the patients were randomized between investigations. Pooled patient preferences were estimated to be 52% (CI 95%: 41–63%) for colon capsule endoscopy and 45% (CI 95%: 33–57%) for conventional colonoscopy: not indicating a significant difference. Procedural adverse events were rarely reported by patients for either investigation. The tolerability was high for both colon capsule endoscopy and conventional colonoscopy. Patient preferences for conventional colonoscopy and colon capsule endoscopy were not significantly different. Procedural adverse events were rare and the tolerability for colon capsule endoscopy was consistently reported higher or equal to that of conventional colonoscopy.</p>}},
  author       = {{Deding, Ulrik and Valdivia, Pablo Cortegoso and Koulaouzidis, Anastasios and Baatrup, Gunnar and Toth, Ervin and Spada, Cristiano and Fernández-Urién, Ignacio and Pennazio, Marco and Bjørsum-Meyer, Thomas}},
  issn         = {{2075-4418}},
  keywords     = {{Colon capsule endoscopy; Colonoscopy; Endoscopy; Patient-reported outcomes}},
  language     = {{eng}},
  number       = {{9}},
  publisher    = {{MDPI AG}},
  series       = {{Diagnostics}},
  title        = {{Patient-reported outcomes and preferences for colon capsule endoscopy and colonoscopy : A systematic review with meta-analysis}},
  url          = {{http://dx.doi.org/10.3390/diagnostics11091730}},
  doi          = {{10.3390/diagnostics11091730}},
  volume       = {{11}},
  year         = {{2021}},
}