suPARnostic : an advanced predictive tool for detecting recurrence in renal cell carcinoma
(2023) In BMC Urology 23(1).- Abstract
Background: Plasma soluble urokinase-type Plasminogen Activator Receptor (suPAR) predicts disease aggressiveness in renal cell carcinoma (ccRCC), but its prognostic accuracy has not been investigated. To investigate the prognostic accuracy of preoperative plasma suPAR in patients who received curative treatment for initially localized ccRCC. Methods: We retrospectively analyzed plasma samples stored in the Danish National Biobank between 2010 and 2015 from 235 patients with ccRCC at any stage. Relationships with outcome analyzed using univariate and multiple logistic Cox regression analysis. Results: There were 235 patients with ccRCC. The median follow-up period was 7.7 years. In univariate analysis suPAR ≥ 6 ng/mL was significantly... (More)
Background: Plasma soluble urokinase-type Plasminogen Activator Receptor (suPAR) predicts disease aggressiveness in renal cell carcinoma (ccRCC), but its prognostic accuracy has not been investigated. To investigate the prognostic accuracy of preoperative plasma suPAR in patients who received curative treatment for initially localized ccRCC. Methods: We retrospectively analyzed plasma samples stored in the Danish National Biobank between 2010 and 2015 from 235 patients with ccRCC at any stage. Relationships with outcome analyzed using univariate and multiple logistic Cox regression analysis. Results: There were 235 patients with ccRCC. The median follow-up period was 7.7 years. In univariate analysis suPAR ≥ 6 ng/mL was significantly associated with overall survival (OS) and recurrence-free survival (RFS). Patients with elevated suPAR were more likely to recur, with a Hazard Ratio (HR) of 2.3 for RFS. In multiple logistic regression, suPAR ≥ 6 ng/mL remained a negative predictor of OS and RFS. Limitations include retrospective study design, wide confidence intervals, and tumor subtype heterogeneity bias. Conclusions: ccRCC patients with high plasma suPAR concentrations are at an elevated risk of disease recurrence and see lower OS. suPAR is a promising surveillance tool to more precisely follow up with ccRCC patients and detect future recurrences. Patient Summary: In this study, we showed that new type of liquid marker in blood plasma, called suPAR, is associated to a higher risk of kidney cancer recurrence when elevated above 6ng/mL. We also showed suPAR to independently be able to predict patients overall and recurrence free survival in patient with any stage of kidney cancer.
(Less)
- author
- Azawi, Nessn ; Mosholt, Karina Sif Sondergaard ; Fryd, Nathalie Demuth ; Lund, Lars ; Brignone, Juan Ignacio ; Hvid, Nanna ; Wulf-Johansson, Helle ; Pedersen, Ole Birger Vesterager ; Saekmose, Susanne Gjørup and Dabestani, Saeed LU
- organization
- publishing date
- 2023-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarker, Clear cell kidney Cancer, Liquid biopsy, Prognostication, Recurrence free survival
- in
- BMC Urology
- volume
- 23
- issue
- 1
- article number
- 168
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:37875832
- scopus:85174814193
- ISSN
- 1471-2490
- DOI
- 10.1186/s12894-023-01337-z
- language
- English
- LU publication?
- yes
- id
- 2b7e6e94-9e66-44c2-abc3-99eeaa4b87ae
- date added to LUP
- 2023-12-07 13:32:21
- date last changed
- 2024-04-20 07:49:56
@article{2b7e6e94-9e66-44c2-abc3-99eeaa4b87ae,
abstract = {{<p>Background: Plasma soluble urokinase-type Plasminogen Activator Receptor (suPAR) predicts disease aggressiveness in renal cell carcinoma (ccRCC), but its prognostic accuracy has not been investigated. To investigate the prognostic accuracy of preoperative plasma suPAR in patients who received curative treatment for initially localized ccRCC. Methods: We retrospectively analyzed plasma samples stored in the Danish National Biobank between 2010 and 2015 from 235 patients with ccRCC at any stage. Relationships with outcome analyzed using univariate and multiple logistic Cox regression analysis. Results: There were 235 patients with ccRCC. The median follow-up period was 7.7 years. In univariate analysis suPAR ≥ 6 ng/mL was significantly associated with overall survival (OS) and recurrence-free survival (RFS). Patients with elevated suPAR were more likely to recur, with a Hazard Ratio (HR) of 2.3 for RFS. In multiple logistic regression, suPAR ≥ 6 ng/mL remained a negative predictor of OS and RFS. Limitations include retrospective study design, wide confidence intervals, and tumor subtype heterogeneity bias. Conclusions: ccRCC patients with high plasma suPAR concentrations are at an elevated risk of disease recurrence and see lower OS. suPAR is a promising surveillance tool to more precisely follow up with ccRCC patients and detect future recurrences. Patient Summary: In this study, we showed that new type of liquid marker in blood plasma, called suPAR, is associated to a higher risk of kidney cancer recurrence when elevated above 6ng/mL. We also showed suPAR to independently be able to predict patients overall and recurrence free survival in patient with any stage of kidney cancer.</p>}},
author = {{Azawi, Nessn and Mosholt, Karina Sif Sondergaard and Fryd, Nathalie Demuth and Lund, Lars and Brignone, Juan Ignacio and Hvid, Nanna and Wulf-Johansson, Helle and Pedersen, Ole Birger Vesterager and Saekmose, Susanne Gjørup and Dabestani, Saeed}},
issn = {{1471-2490}},
keywords = {{Biomarker; Clear cell kidney Cancer; Liquid biopsy; Prognostication; Recurrence free survival}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Urology}},
title = {{suPARnostic : an advanced predictive tool for detecting recurrence in renal cell carcinoma}},
url = {{http://dx.doi.org/10.1186/s12894-023-01337-z}},
doi = {{10.1186/s12894-023-01337-z}},
volume = {{23}},
year = {{2023}},
}