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Comparison of Triglyceride-Glucose (TyG) Index and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) Index in Prediction of Male Hypogonadism

Hazir, Berk LU orcid ; Salonia, Andrea ; Giwercman, Aleksander LU and Elenkov, Angel LU (2024) In Andrologia 2024.
Abstract

Several studies have shown the association between decreased insulin sensitivity and the risk of male hypogonadism. Homeostatic model assessment of insulin resistance (HOMA-IR) is a well-established marker of decreased insulin sensitivity. The triglyceride-glucose index (TyG), calculated as ln fasting triglyceride mg/dL× fasting glucose mg/dL/2, was recently suggested to be a cheaper and a reliable surrogate marker to detect insulin resistance (IR). Our aim was to compare the performance of those two indexes in the prediction of male hypogonadism. The data on 192 men from infertile couples (18-50 years; sperm concentration <20 x 106/mL) and 199 population-based matched controls collected during the years 2009-2012 (baseline) were... (More)

Several studies have shown the association between decreased insulin sensitivity and the risk of male hypogonadism. Homeostatic model assessment of insulin resistance (HOMA-IR) is a well-established marker of decreased insulin sensitivity. The triglyceride-glucose index (TyG), calculated as ln fasting triglyceride mg/dL× fasting glucose mg/dL/2, was recently suggested to be a cheaper and a reliable surrogate marker to detect insulin resistance (IR). Our aim was to compare the performance of those two indexes in the prediction of male hypogonadism. The data on 192 men from infertile couples (18-50 years; sperm concentration <20 x 106/mL) and 199 population-based matched controls collected during the years 2009-2012 (baseline) were evaluated retrospectively. Half of these subjects (72 subfertile men and 122 controls) were reinvestigated 5-10 years later (median year (range): 7 (5-10)). The patients receiving any hormonal therapy were excluded. Hypogonadism was defined as fasting, morning serum testosterone below 12 nmol/L. In receiver operating characteristic curve analysis, the optimal diagnostic cutoff values for baseline HOMA-IR and TyG to predict MetS at re-examination were 2.68 (Area Under Curve (AUC) = 0.886, p < 0.001) and 8.60 (AUC = 0.816, p <0.001), respectively. Moreover, in binary logistic regression analysis performed on the whole cohort using these thresholds for high values of HOMA-IR and high TyG, the odds-ratios (ORs) for hypogonadism were 6.48 (95% Confidence Interval (CI): 3.77-11.2; p <0.001) and 3.58 (95% CI: 2.17-5.94; p <0.001), respectively. Even though high HOMA-IR levels provided better risk estimates, high TyG was also highly related to the risk of hypogonadism. These markers can be utilized to identify men being at high risk of hypogonadism.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Andrologia
volume
2024
article number
1865552
publisher
Wiley-VCH Verlag
external identifiers
  • scopus:85195257546
ISSN
0303-4569
DOI
10.1155/2024/1865552
language
English
LU publication?
yes
id
2b7ed140-250a-4341-a404-2cfce91219c3
date added to LUP
2024-10-07 14:41:27
date last changed
2025-04-04 15:11:32
@article{2b7ed140-250a-4341-a404-2cfce91219c3,
  abstract     = {{<p>Several studies have shown the association between decreased insulin sensitivity and the risk of male hypogonadism. Homeostatic model assessment of insulin resistance (HOMA-IR) is a well-established marker of decreased insulin sensitivity. The triglyceride-glucose index (TyG), calculated as ln fasting triglyceride mg/dL× fasting glucose mg/dL/2, was recently suggested to be a cheaper and a reliable surrogate marker to detect insulin resistance (IR). Our aim was to compare the performance of those two indexes in the prediction of male hypogonadism. The data on 192 men from infertile couples (18-50 years; sperm concentration &lt;20 x 106/mL) and 199 population-based matched controls collected during the years 2009-2012 (baseline) were evaluated retrospectively. Half of these subjects (72 subfertile men and 122 controls) were reinvestigated 5-10 years later (median year (range): 7 (5-10)). The patients receiving any hormonal therapy were excluded. Hypogonadism was defined as fasting, morning serum testosterone below 12 nmol/L. In receiver operating characteristic curve analysis, the optimal diagnostic cutoff values for baseline HOMA-IR and TyG to predict MetS at re-examination were 2.68 (Area Under Curve (AUC) = 0.886, p &lt; 0.001) and 8.60 (AUC = 0.816, p &lt;0.001), respectively. Moreover, in binary logistic regression analysis performed on the whole cohort using these thresholds for high values of HOMA-IR and high TyG, the odds-ratios (ORs) for hypogonadism were 6.48 (95% Confidence Interval (CI): 3.77-11.2; p &lt;0.001) and 3.58 (95% CI: 2.17-5.94; p &lt;0.001), respectively. Even though high HOMA-IR levels provided better risk estimates, high TyG was also highly related to the risk of hypogonadism. These markers can be utilized to identify men being at high risk of hypogonadism.</p>}},
  author       = {{Hazir, Berk and Salonia, Andrea and Giwercman, Aleksander and Elenkov, Angel}},
  issn         = {{0303-4569}},
  language     = {{eng}},
  publisher    = {{Wiley-VCH Verlag}},
  series       = {{Andrologia}},
  title        = {{Comparison of Triglyceride-Glucose (TyG) Index and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) Index in Prediction of Male Hypogonadism}},
  url          = {{http://dx.doi.org/10.1155/2024/1865552}},
  doi          = {{10.1155/2024/1865552}},
  volume       = {{2024}},
  year         = {{2024}},
}