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Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry

Grande, Xenia ; Sauvage, Magdalena ; Becke, Andreas ; Düzel, Emrah and Berron, David LU (2022) In eLife 11.
Abstract

Scene and object information reach the entorhinal-hippocampal circuitry in partly segregated cortical processing streams. Converging evidence suggests that such information-specific streams organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis of hippocampal subiculum and CA1. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and the subiculum. We identify entorhinal subregions based on preferential functional connectivity with perirhinal Area 35 and 36, parahippocampal and retrosplenial cortical sources (referred to as ECArea35-based,... (More)

Scene and object information reach the entorhinal-hippocampal circuitry in partly segregated cortical processing streams. Converging evidence suggests that such information-specific streams organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis of hippocampal subiculum and CA1. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and the subiculum. We identify entorhinal subregions based on preferential functional connectivity with perirhinal Area 35 and 36, parahippocampal and retrosplenial cortical sources (referred to as ECArea35-based, ECArea36-based, ECPHC-based, ECRSC-based, respectively). Our data show specific scene processing in the functionally connected ECPHC-based and distal subiculum. Another route, that functionally connects the ECArea35-based and a newly identified ECRSC-based with the subiculum/CA1 border, however, shows no selectivity between object and scene conditions. Our results are consistent with transversal information-specific pathways in the human entorhinal-hippocampal circuitry, with anatomically organized convergence of cortical processing streams and a unique route for scene information. Our study thus further characterizes the functional organization of this circuitry and its information-specific role in memory function.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
eLife
volume
11
article number
e76479
publisher
eLife Sciences Publications
external identifiers
  • pmid:36222669
  • scopus:85141500277
ISSN
2050-084X
DOI
10.7554/eLife.76479
language
English
LU publication?
yes
id
2becd46b-9df2-44d2-b336-51954e75402b
date added to LUP
2022-12-05 11:40:58
date last changed
2024-04-18 15:46:17
@article{2becd46b-9df2-44d2-b336-51954e75402b,
  abstract     = {{<p>Scene and object information reach the entorhinal-hippocampal circuitry in partly segregated cortical processing streams. Converging evidence suggests that such information-specific streams organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis of hippocampal subiculum and CA1. Here, we leveraged ultra-high field functional imaging and advance Maass, Berron et al. (2015) who report two functional routes segregating the entorhinal cortex (EC) and the subiculum. We identify entorhinal subregions based on preferential functional connectivity with perirhinal Area 35 and 36, parahippocampal and retrosplenial cortical sources (referred to as EC<sub>Area35-based</sub>, EC<sub>Area36-based</sub>, EC<sub>PHC-based</sub>, EC<sub>RSC-based</sub>, respectively). Our data show specific scene processing in the functionally connected EC<sub>PHC-based</sub> and distal subiculum. Another route, that functionally connects the EC<sub>Area35-based</sub> and a newly identified EC<sub>RSC-based</sub> with the subiculum/CA1 border, however, shows no selectivity between object and scene conditions. Our results are consistent with transversal information-specific pathways in the human entorhinal-hippocampal circuitry, with anatomically organized convergence of cortical processing streams and a unique route for scene information. Our study thus further characterizes the functional organization of this circuitry and its information-specific role in memory function.</p>}},
  author       = {{Grande, Xenia and Sauvage, Magdalena and Becke, Andreas and Düzel, Emrah and Berron, David}},
  issn         = {{2050-084X}},
  language     = {{eng}},
  publisher    = {{eLife Sciences Publications}},
  series       = {{eLife}},
  title        = {{Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry}},
  url          = {{http://dx.doi.org/10.7554/eLife.76479}},
  doi          = {{10.7554/eLife.76479}},
  volume       = {{11}},
  year         = {{2022}},
}